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NSFL1C Antibody

  • 货号：
    CSB-PA892163DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: NSFL1C antibody at 6.3μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: A431 whole cell lysate
      Lane 3: 293T whole cell lysate
      Lane 4: Rat liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 41, 38, 29 kDa
      Observed band size: 41, 130 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA892163DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA892163DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NSFL1C Polyclonal antibody
  • Uniprot No.：
    Q9UNZ2
  • 基因名：
  • 别名：
    DJ776F14.1 antibody; MGC3347 antibody; NSF1C_HUMAN antibody; NSFL1 (p97) cofactor (p47) antibody; NSFL1 cofactor p47 antibody; NSFL1C antibody; OTTHUMP00000029972 antibody; OTTHUMP00000029974 antibody; p47 antibody; P47 protein antibody; p97 cofactor p47 antibody; SHP1 homolog antibody; UBX domain protein 2C antibody; UBX domain-containing protein 2C antibody; UBX1 antibody; UBXD10 antibody; UBXN2C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human NSFL1 cofactor p47 protein (1-185AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
  • 基因功能参考文献：
    1. p47 promotes, whereas SASK1 delays the degradation of a single ERAD substrate, alpha-TCR. Additionally, we found that SAKS1 selectively inhibits the degradation of ERAD substrates without affecting cytosolic proteasomal substrates. PMID: 27785701
    2. The present results for the first time demonstrate that BDNF induces NADPH oxidase -derived reactive oxygen species generation through activation of p47 phox in a TrkB receptor-dependent manner PMID: 24612679
    3. human p37/p47 and their C. elegans orthologue UBXN-2 regulate centrosome function in prophase by limiting the recruitment of Aurora A PMID: 23649807
    4. The binding of p47 to polyubiquitinated NEMO triggers the lysosomal degradation of NEMO, thereby inhibiting IKK activation. PMID: 22990857
  • 亚细胞定位：
    Nucleus. Golgi apparatus, Golgi stack. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    NSFL1C family
  • 数据库链接：

    HGNC: 15912

    OMIM: 606610

    KEGG: hsa:55968

    STRING: 9606.ENSP00000418529

    UniGene: Hs.12865