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NSMAF Antibody

  • 货号：
    CSB-PA856416LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA856416LA01HU diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA856416LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NSMAF Polyclonal antibody
  • Uniprot No.：
    Q92636
  • 基因名：
    NSMAF
  • 别名：
    NSMAF antibody; FANProtein FAN antibody; Factor associated with neutral sphingomyelinase activation antibody; Factor associated with N-SMase activation antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein FAN protein (1-233AA )
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NSMAF Antibody (CSB-PA856416LA01HU)，的标记方式是Non-conjugated。对于NSMAF Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA856416LB01HU NSMAF Antibody, HRP conjugated ELISA
    FITC CSB-PA856416LC01HU NSMAF Antibody, FITC conjugated
    Biotin CSB-PA856416LD01HU NSMAF Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
  • 基因功能参考文献：
    1. these data identify a novel caspase-2-interacting factor, FAN, and expand the role for the enzyme in seemingly non-apoptotic cellular mechanisms. PMID: 29621545
    2. The rs1050504 C > T genotype was observed to be significantly associated with an increased risk for developing pulmonary tuberculosis. PMID: 29115933
    3. The interaction of FAN with receptor for activated C-kinase 1 (RACK1) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN. PMID: 12391233
    4. sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase PMID: 15653433
    5. Regulation of NSMAF by TNF-alpha involves PRKCD in lung epithelial cells. PMID: 18653803

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  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 8017

    OMIM: 603043

    KEGG: hsa:8439

    STRING: 9606.ENSP00000411012

    UniGene: Hs.372000