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NSUN4 Antibody

  • 货号：
    CSB-PA850270LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, SH-SY5Y whole cell lysate, K562 whole cell lysate
      All lanes: NSUN4 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 44, 17, 22, 38 kDa
      Observed band size: 44 kDa
    • Immunofluorescence staining of Human testicular tissue with CSB-PA850270LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunofluorescence staining of human prostate tissue with CSB-PA850270LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunofluorescence staining of human colorectal cancer tissue with CSB-PA850270LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NSUN4 Polyclonal antibody
  • Uniprot No.：
    Q96CB9
  • 基因名：
    NSUN4
  • 别名：
    5 methylcytosine rRNA methyltransferase NSUN4 antibody; EC=2.1.1.- antibody; NOL1/NOP2/Sun domain family member 4 antibody; NOL1/NOP2/Sun domain family, member 4 antibody; NOP2/Sun domain family, member 4 antibody; Nsun4 antibody; NSUN4_HUMAN antibody; Putative methyltransferase NSUN4 antibody; RP4-603I14.2 antibody; Shtap antibody; Sperm head and tail associated protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human 5-methylcytosine rRNA methyltransferase NSUN4 protein (26-284AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NSUN4 Antibody (CSB-PA850270LA01HU)，的标记方式是Non-conjugated。对于NSUN4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850270LB01HU NSUN4 Antibody, HRP conjugated ELISA
    FITC CSB-PA850270LC01HU NSUN4 Antibody, FITC conjugated
    Biotin CSB-PA850270LD01HU NSUN4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.
  • 基因功能参考文献：
    1. It involves in epigenetic changes during the progression of Alzheimer disease pathology. PMID: 24387984
    2. analysis of the 3D crystal structure of the human MTERF4-NSUN4 complex PMID: 22949673
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19086053
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
  • 数据库链接：

    HGNC: 31802

    OMIM: 615394

    KEGG: hsa:387338

    STRING: 9606.ENSP00000419740

    UniGene: Hs.163424