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NT5C2 Antibody

  • 货号：
    CSB-PA23789A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue
      All lanes: NT5C2 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 65, 62 kDa
      Observed band size: 65 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA23789A0Rb at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NT5C2 Polyclonal antibody
  • Uniprot No.：
    P49902
  • 基因名：
    NT5C2
  • 别名：
    5' nucleotidase (purine) cytosolic type B antibody; 5NTC_HUMAN antibody; cN II antibody; Cytosolic 5''-nucleotidase II antibody; Cytosolic IMP/GMP-specific 5'-nucleotidase antibody; Cytosolic purine 5' nucleotidase antibody; Cytosolic purine 5''-nucleotidase antibody; GMP antibody; NT5B antibody; nt5c2 antibody; NT5CP antibody; NUCLEOTIDASE; 5-PRIME; CYTOSOLIC II antibody; NUCLEOTIDASE; 5-PRIME; TYPE B antibody; PNT5 antibody; PURINE 5-PRIME-NUCLEOTIDASE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Cytosolic purine 5\'-nucleotidase protein (487-553AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NT5C2 Antibody (CSB-PA23789A0Rb)，的标记方式是Non-conjugated。对于NT5C2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA23789B0Rb NT5C2 Antibody, HRP conjugated ELISA
    FITC CSB-PA23789C0Rb NT5C2 Antibody, FITC conjugated
    Biotin CSB-PA23789D0Rb NT5C2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
  • 基因功能参考文献：
    1. NT5C2 mutations seem to have a broad clinical spectrum and should be sought in patients manifesting either as uncomplicated or complicated spastic paraplegia PMID: 28884889
    2. Using data from a large-scale genome-wide association study of schizophrenia, study identified several potentially functional variants relating to miRNA function with our top finding being a schizophrenia protective allele that disrupts miR-206s binding to NT5C2 thus leading to increased expression of this gene. PMID: 27424800
    3. acute lymphoblastic leukemia-specific mutations affect regulation of cN-II PMID: 27756303
    4. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus PMID: 27004590
    5. NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population. PMID: 27901213
    6. The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein. PMID: 28327087
    7. Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors. PMID: 26259531
    8. cN-II co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain. PMID: 25811392
    9. Data indicate that type II cytosolic 5'-nucleotidase (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival. PMID: 25857773
    10. Four novel body mass index-associated loci near the KCNQ1(rs2237892), ALDH2/MYL2 (rs671, rs12229654), ITIH4 (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations. PMID: 24861553
    11. These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia PMID: 23377183
    12. results highlight the prominent role of relapse-specific mutations in NT5C2 as a mechanism of resistance to 6-Mercaptopurine and a genetic driver of relapse in acute lymphoblastic leukemia PMID: 23377281
    13. analysis of Drosophila and human 7-methyl GMP-specific nucleotidases PMID: 23223233
    14. Polymorphisms in the CYP17A1 and NT5C2 genes influence a reduction in both visceral and subcutaneous fat mass in Japanese women. PMID: 22071413
    15. seven high-resolution structures of human cN-II, including a ligand-free form and complexes with various substrates and effectors, were presented. PMID: 21396942
    16. cN-II has a role in protecting against progression of non-small cell lung cancer PMID: 15923058
    17. the expression level of cN-II mRNA might be a prognostic factor of high-risk MDS. PMID: 17350683
    18. Data describe the crystal structure of human cytosolic 5'-nucleotidase II and discuss its allosteric regulation and substrate recognition. PMID: 17405878
    19. In leukoblasts from 82 patients with acute myeloid leukemia, various extent and frequency of differential allelic expression in the CDA, DCK, NT5C2, NT5C3, and TP53 genes was observed. PMID: 18775979
    20. The DCK/cN-II ratio was again proportional to ara-CTP production and to ara-C sensitivity. PMID: 19428333

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  • 相关疾病：
    Spastic paraplegia 45, autosomal recessive (SPG45)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    5'(3')-deoxyribonucleotidase family
  • 数据库链接：

    HGNC: 8022

    OMIM: 600417

    KEGG: hsa:22978

    STRING: 9606.ENSP00000339479

    UniGene: Hs.734531