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  4. NTF4 Antibody

NTF4 Antibody

  • 货号：
    CSB-PA020161
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P34130
  • 基因名：
  • 别名：
    GLC10 antibody; GLC1O antibody; Neurotrophic factor 4 antibody; Neurotrophic factor 5 antibody; Neurotrophin 4 antibody; Neurotrophin 4/5 antibody; Neurotrophin 5 (neurotrophin 4/5) antibody; Neurotrophin 5 antibody; Neurotrophin-4 antibody; Neurotrophin-5 antibody; Neutrophic factor 4 antibody; Neutrophic factor 5 antibody; NT 4 antibody; NT 4/5 antibody; NT 5 antibody; NT-4 antibody; NT-5 antibody; NT4 antibody; NT4/5 antibody; NT4P antibody; NT5 antibody; NTF4 antibody; NTF4_HUMAN antibody; NTF5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NT-4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Target-derived survival factor for peripheral sensory sympathetic neurons.
  • 基因功能参考文献：
    1. Elevated intra-amniotic levels of docosahexaenoic acid and arachidonic acid in the mid-trimester are correlated with increased NT4 concentrations. PMID: 24607879
    2. The NTF4 variants p.Gly157Ala and p.Ala182Val have been shown to be functional mutations, occurring in 2 of a total of 720 Chinese primary open-angle glaucoma patients. PMID: 22815630
    3. NT-4/5 expression is associated with atrophy of the brain-parenchymal fraction measured by magnetic resonance imaging methods in patients with relapsing-remitting multiple sclerosis. PMID: 22036954
    4. Suggest that a dysregulated TrkB/NT4/5 axis may contribute to several of the pathological lesions associated with pulmonary fibrosis, including type 2 alveolar cell hyperplasia and the proliferation of fibroblasts. PMID: 21330466
    5. neurotrophin 4 contributes to breast cancer cell survival and can serve as prospective target to inhibit tumor growth PMID: 21350004
    6. In vitro follicular assembly is significantly increased in fetal ovaries cultured with NT-4. PMID: 20447632
    7. Identification of a single mutation in our study suggests that NTF4 mutations are a rare cause of primary open-angle glaucoma (0.6%, 95%CI 0.02%-3.16%) in Chinese people. PMID: 20806036
    8. present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population. PMID: 20463313
    9. Expression of human NTF4 was unchanged during gestation in the developping ovary. PMID: 20175187
    10. No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. PMID: 20215012
    11. A mechanism to understand the defect associated with variant BDNF and provide a framework two ligands for BDNF and NT-4. PMID: 15987945
    12. Re-expression of the p75NTR appears to partially reverse de-differentiation of prostate cancer cells by up-regulating the expression of CRABPI for localized sequestration of retinoids. PMID: 16316409
    13. Results revealed the expression of NT-4/5 mainly in oocytes and, in a minority of samples, also in the granulosa cells (GCs). PMID: 16648150
    14. These novel data demonstrate that neurotrophins influence ASM [Ca(2+)](i) and force regulation and suggest a potential role for neurotrophins in airway diseases PMID: 16648236
    15. Neurotrophin 4/5 plays a role in the proliferation and differentiation of periodontal ligament cells. PMID: 18980528
    16. Data show that the levels of NT-4/5 levels are significantly higher in bipolar disorder patients than in controlsNT-4/5. immunocontent alterations in bipolar disorder. PMID: 19081579
    17. NTF4 mutations impair neurotrophin-4 signaling in patients with primary open-angle glaucoma and lead to decreased activation of TrkB PMID: 19765683

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  • 相关疾病：
    Glaucoma 1, open angle, O (GLC1O)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    NGF-beta family
  • 组织特异性：
    Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
  • 数据库链接：

    HGNC: 8024

    OMIM: 162662

    KEGG: hsa:4909

    STRING: 9606.ENSP00000301411

    UniGene: Hs.266902