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NTRK3 Antibody

  • 货号：
    CSB-PA005017
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using Trk C Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q16288
  • 基因名：
  • 别名：
    EC 2.7.10.1 antibody; ETS related protein neurotrophic receptor tyrosine kinase fusion antibody; ETS related protein neurotrophic receptor tyrosine kinase fusion protein antibody; ETV6 NTRK3 fusion antibody; GP145 TrkC antibody; gp145(trkC) antibody; GP145-TrkC antibody; GP145TrkC antibody; Neurotrophic tyrosine kinase receptor type 3 antibody; Neurotrophin 3 receptor antibody; NT 3 growth factor receptor antibody; NT 3 growth factor receptor precursor antibody; NT 3 receptor antibody; NT-3 growth factor receptor antibody; Ntrk3 antibody; NTRK3_HUMAN antibody; OTTHUMP00000192915 antibody; TRK C antibody; Trk-C antibody; TRKC antibody; TrkC tyrosine kinase antibody; Tyrosine kinase receptor C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Trk C.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
  • 基因功能参考文献：
    1. High TrkC mRNA expression appears to be frequent in the sonic hedgehog subgroup and seems not to have a major effect on therapy responsiveness in medulloblastoma patients. PMID: 28695340
    2. Data show that neurotrophin 3 receptor TrkC acts as an activator in tumorigenicity and metastasis of colorectal cancer, and was frequently overexpressed in colorectal cancer (CRC) cells, patients' tumor samples. PMID: 28455963
    3. LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR-128 and miR-485-3p to reduce the luciferase activity of NTRK3 3'UTR. PMID: 27351280
    4. Case Reports: mammary analog secretory carcinoma of the thyroid gland with ETV6 rearrangement and ETV6-NTRK3 gene fusion. PMID: 27282352
    5. The prevalence of ETV6-NTRK3 kinase fusions were determined in papillary thyroid cancer of adult population PMID: 29046324
    6. We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as Mammary analogue secretory carcinoma after next-generation sequencing revealed an ETV6-NTRK3 fusion. PMID: 26884591
    7. 5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA/SDHx/RAS pathways, including two additional cases with FGFR1-TACC1 and ETV6-NTRK3 fusions, are reported. PMID: 27974047
    8. High expression of TrkC is associated with glioblastoma. PMID: 28402394
    9. Study found that copy number variations of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer. PMID: 28746220
    10. we demonstrate the expression of the ETV6-NTRK3 fusion oncogene in a small subset of inflammatory myofibroblastic tumors PMID: 27259007
    11. ETV6-NTRK3 translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly. PMID: 28125451
    12. We report 6 cases of secretory carcinomas of the skin harboring the ETV6-NTRK3 gene fusion PMID: 27631515
    13. A subset of ALK-negative inflammatory myofibroblastic tumour (IMT) have rearrangement of ROS1, ETV6 or NTRK3 as a possible oncogenic mechanism. PMID: 26647767
    14. TrkC-miR2 as a novel regulator of Wnt signaling, which might be a candidate oncogenic colorectal cancer biomarker. PMID: 28100780
    15. Pilot study usee targeted exome sequencing in an attempt to discover novel candidate genes related to Internet Gaming Disorder. Despite a relatively small sample, the targeted exome sequencing was feasible and valuable and revealed that rs2229910 of NTRK3 may be a protective SNP against Internet Gaming Disorder. PMID: 27826991
    16. Case Report: ETV6-NTRK3 translocation in primary cutaneous mammary analog secretory carcinoma. PMID: 27763904
    17. the ETV6-NTRK3 fusion might identify a subset of gastrointestinal stromal tumours with peculiar clinicopathological characteristics PMID: 26606880
    18. TNS1, MET, and TRKC tyrosine-phosphorylated proteins are upregulated during epithelial-mesenchymal transition induced with TGF-beta, and predict the outcome in lung adenocarcinoma patients. PMID: 26216473
    19. SNPs in the NTRK3 gene, pain, physical activity, and fear of falling were directly associated with depressive symptoms in older adults. PMID: 26055783
    20. Molecular analysis of ETV6 gene rearranged mammary analogue secretory carcinoma of salivary glands tumors with lack of classical ETV6-NTRK3 fusion. PMID: 26492182
    21. Spectrum of secretory breast carcinoma with ETV6-NTRK3 gene fusion ranging from low-grade to high-grade histology, with occasional low hormonal receptor expression, simplex genomic profiles, and possible unfavorable course. PMID: 26291510
    22. The role of NTRK3 in in paranoid schizophrenia development in Russians. PMID: 26410934
    23. The overall percentage of NTRK3 gene methylation frequency with subsequent loss of mRNA expression was significantly higher in glioma compared with control samples. PMID: 24840578
    24. Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function. PMID: 25772499
    25. findings suggest a novel pathophysiological mechanism involving NTRK3 in the development of VSDs PMID: 25196463
    26. Report molecular genetic tests for ETV6-NTRK3 for differential diagnosis of mammary analogue secretory carcinoma of the salivary gland. PMID: 25456394
    27. ETV6-NTRK3 rearrangement can be directly induced in thyroid cells by ionizing radiation in vitro and, thus, may represent a novel mechanism of radiation-induced carcinogenesis. PMID: 24327398
    28. NTRK3 genetic variants may influence white matter integrity in brain regions implicated in neuropsychiatric disorders. PMID: 23727532
    29. Results show that TrkC plays physiological role in the pathogenesis of leukemia and have important implications for understanding various hematological malignancies. PMID: 23832765
    30. Report ETV6-NTRK3 gene fusion in mammary analogue secretory carcinoma of salivary glands with high-grade transformation. PMID: 24145651
    31. our findings suggest NTRK3 is a conditional tumor suppressor gene that is commonly inactivated in colorectal cancer by both epigenetic and genetic mechanisms PMID: 23874207
    32. Genetic evidence shows that TrkC and TrkB activation in early cortical neurons depends on transactivation by epidermal growth factor receptor signaling. PMID: 23416450
    33. provide evidence that a mutation of TrkC detected in a sporadic cancer is a loss-of-proapoptotic function mutation PMID: 23341610
    34. ShcD binds to TrkC in a kinase-activity-dependent manner through its PTB and SH2 domains. PMID: 20078941
    35. The significant expression of Trk isoforms among advanced neuroblastoma cases support their role as possible risk assessment tools alongside N-Myc amplification status. PMID: 21728718
    36. SOX2 utilizes a specific binding motif to directly interact with the TRKC regulatory region. PMID: 22265740
    37. TrkC is implicated as a functional PDNF receptor in cell entry, independently of sialic acid recognition, mediating broad T. cruzi infection both in vitro and in vivo. PMID: 21788388
    38. Low TRKC is associated with low vincristine and lomustine response in medulloblastoma. PMID: 21617231
    39. Mesenchymal stem cells modified by adenovirus carrying the TrkC gene are further promoted to differentiate into neuron-like cells with the potency of forming synapses by overexpressing the NT-3 gene in Schwann cells. PMID: 19680743
    40. We have characterized a novel ETV6-NTRK3 fusion transcript which has not been previously described in AML FAB M0 by FISH and RACE PCR. PMID: 21401966
    41. NT3 and its receptor may be involved in early folliculogenesis, particularly in the activation of primordial follicles. PMID: 21392742
    42. This study demonistrated that Intron 12 in NTRK3 is associated with bipolar disorder. PMID: 20554328
    43. Overexpression of TrkC is associated with breast tumor growth and metastasis. PMID: 20802235
    44. Findings suggest that mutations in RET and NTRK3 acting together are necessary and sufficient for the appearance of Hirschsprung disease and the EDN3 mutation acts as a phenotype modifier. PMID: 19556619
    45. Study identified the previously reported pathogenic mutation of NTRK3 in a KRAS/BRAF wild-type tumor and 2 somatic mutations in the Src family of kinases (YES1 and LYN) that would be expected to cause structural changes. PMID: 19893451
    46. Although TrkB and TrkC signals mediating survival are largely similar, TrkB and TrkC signals required for maintenance of target innervation in vivo are regulated by distinct mechanisms. PMID: 11877382
    47. Expression of the ETV6-NTRK3 gene fusion is a primary event in human secretory breast carcinoma. PMID: 12450792
    48. ETV6-NTRK3.IRS-1 complex formation through the NTRK3 C terminus is essential for ETV6-NTRK3 transformation PMID: 14668342
    49. While survival rates were higher for patients with high TrkC expression, these differences were not statistically significant. PMID: 15198123
    50. truncated trkC is prevalent in the human prefrontal cortex and that neurons and glia may be responsive to NT-3 throughout life PMID: 15932601

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  • 相关疾病：
    Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 组织特异性：
    Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
  • 数据库链接：

    HGNC: 8033

    OMIM: 191316

    KEGG: hsa:4916

    STRING: 9606.ENSP00000354207

    UniGene: Hs.185701