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NUCB1 Antibody

  • 货号：
    CSB-PA016145GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q02818
  • 基因名：
    NUCB1
  • 别名：
    CALNUC antibody; FLJ40471 antibody; NUC antibody; NUCB 1 antibody; NUCB1 antibody; NUCB1_HUMAN antibody; Nucleobindin 1 antibody; Nucleobindin-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NUCB1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins).
  • 基因功能参考文献：
    1. Data suggest that calnuc (nucleobindin 1) is possibly involved in controlling protein unfolding diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), prion disease, and type II diabetes. PMID: 27997158
    2. Calnuc depletion causes the misdelivery to and degradation in lysosomes of cationic-independent mannose-6-phosphate receptor and Sortilin . PMID: 26756199
    3. nesfatin-1 has a role in thyroid dysfunction in patients with T2DM PMID: 24995340
    4. The serine protease activity of calnuc is allosterically regulated by Zn2+ binding and its interaction with G protein alpha subunit. PMID: 23195954
    5. postulate that the engineered forms of NUCB1 prevent hIAPP fibril formation by a mechanism where protofibril-like species are "capped" to prevent further fibril assembly and maturation PMID: 22542527
    6. structural basis for the properties of Calnuc and NUCB2 binding to Galpha subunits and its regulation by calcium ions. PMID: 21653697
    7. Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1. PMID: 20679342
    8. Comparison between the structure of nucleobindin and other EF-hand proteins sheds light into the dual function of nucleobindin as Ca2+ storage (buffer) and Ca2+ sensor. PMID: 15287731
    9. Calnuc protein may be a tumor-associated antigen (TAA) that induces autoantibody response in human cancers PMID: 17390015
    10. NUCB1 is the first-identified, Golgi-localized negative feedback regulator in the ATF6-mediated branch of the UPR PMID: 17686766
    11. results suggest that the functions of nucleobindins could be modulated by caspase-mediated cleavage in apoptosis PMID: 18154733
    12. Proline residue at the +2-position (Pro(+2)) from the signal peptide cleavage site is the determinant of NUCB1 protein export from the ER and subsequent transport to the Golgi. PMID: 19656946

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  • 亚细胞定位：
    Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side. Cytoplasm. Secreted.
  • 蛋白家族：
    Nucleobindin family
  • 组织特异性：
    Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.
  • 数据库链接：

    HGNC: 8043

    OMIM: 601323

    KEGG: hsa:4924

    STRING: 9606.ENSP00000263273

    UniGene: Hs.631602