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NUP107 Antibody

  • 货号：
    CSB-PA016188GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P57740
  • 基因名：
    NUP107
  • 别名：
    107 kDa nucleoporin antibody; NU107_HUMAN antibody; Nuclear pore complex protein Nup107 antibody; Nucleoporin 107kDa antibody; Nucleoporin Nup107 antibody; NUP107 antibody; NUP84 antibody; NUP84; yeast; homolog of antibody; OTTHUMP00000240604 antibody; OTTHUMP00000240606 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NUP107
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis.
  • 基因功能参考文献：
    1. Whole exome sequencing identified a novel and rare missense variant in the NUP107 gene (c.1063C>T, p.R355C) in both sisters with HH. PMID: 29363275
    2. NUP107 was suggested as a candidate in a family with nephrotic syndrome and developmental delay. PMID: 28280135
    3. Associations between biallelic NUP107 mutations and age at onset in children with steroid-resistant nephrotic syndrome. PMID: 27190346
    4. a variant in the 3'-UTR region Nup107 unique to sensitivity to platinum in ovarian cancer, was identified. PMID: 28562428
    5. Nup107-160 complex and its partner Elys dynamically colocalize with Nup98 and CRM1 into endogenous GLFG bodies present in specific HeLa sublines. PMID: 25904327
    6. a recessive missense mutation in nucleoporin-107 (NUP107, c.1339G>A, p.D447N). This mutation segregated with the XX-GD phenotype and was not present in available databases or in 150 healthy ethnically matched controls. PMID: 26485283
    7. The central domain of Nup107 interfered with Apaf-1 nuclear translocation upon genotoxic stress, resulting in a marked reduction of Chk-1 activation and cell cycle arrest. PMID: 25695197
    8. Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. PMID: 26411495
    9. The functions have been ascribed to the NUP107 complex, ranging from Nuclear Pore Complex (NPC) assembly to mRNA export to cell differentiation. PMID: 22713280
    10. Study shows that 32 copies of the Nup107 subcomplex assemble into two reticulated rings, one each at the cytoplasmic and nuclear face of the nuclear pore complex. PMID: 24315095
    11. The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. PMID: 22031293
    12. did a Trypan Blue cell viability assay and it showed increased cell death in NUP107 transfected cells than untreated control PMID: 20490895
    13. These findings support the notion that Nup107 may contribute significantly to the regulation of cell fate in aged and transformed cells by modulating nuclear trafficking of signal molecules. PMID: 20833136
    14. A major function of the Nup107 complex in mitosis is to ensure the proper localization of the chromosome passenger complex at the centromere. PMID: 19864462
    15. Data show that Nup107-160 promotes spindle assembly through Ran-GTP-regulated nucleation of microtubules by gamma-TuRC at kinetochores, and reveal a relationship between nucleoporins and the microtubule cytoskeleton. PMID: 20081840
    16. Nup107 functions as a keystone Nup that is required for the assembly of a subset of Nups into the nuclear pore complex PMID: 12552102
    17. Nup107-160 complex is dynamic in mitosis and that it promotes spindle assembly in a manner that is distinct from its functions at interphase nuclear pores. PMID: 16807356
    18. phosphorylation does not affect interactions within the Nup107-160 subcomplex, but regulates the association of the subcomplex with the NPC and other proteins PMID: 17360435
    19. These data thus provide the first molecular clues underlying the function of the human Nup107-160 complex at kinetochores. PMID: 17363900
    20. When complexed with NUP133, this complex will give the first insights into the protein-protein interactions within a core module of the nuclear pore complex. PMID: 17768364

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  • 相关疾病：
    Nephrotic syndrome 11 (NPHS11)
  • 亚细胞定位：
    Nucleus membrane. Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    Nucleoporin Nup84/Nup107 family
  • 组织特异性：
    Ubiquitously expressed in fetal and adult tissues.
  • 数据库链接：

    HGNC: 29914

    OMIM: 607617

    KEGG: hsa:57122

    STRING: 9606.ENSP00000229179

    UniGene: Hs.524574