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NUP85 Antibody

  • 货号：
    CSB-PA016206GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BW27
  • 基因名：
    NUP85
  • 别名：
    85 kDa nucleoporin antibody; FLJ12549 antibody; FROUNT antibody; Frount protein antibody; Nuclear pore complex protein nucleoporin 85 kDa antibody; nuclear pore complex protein nucleoporin Nup75 antibody; Nuclear pore complex protein Nup85 antibody; Nucleoporin 85 antibody; Nucleoporin 85kDa antibody; Nucleoporin nucleoporin 85kDa antibody; Nucleoporin Nup75 antibody; Nucleoporin NUP85 antibody; nucleoporin, 75-KD antibody; Nucleoporin85 antibody; Nup 75 antibody; NUP 85 antibody; Nup75 antibody; nup85 antibody; NUP85_HUMAN antibody; PCN antibody; PCNT 1 antibody; PCNT antibody; PCNT, formerly antibody; PCNT1 antibody; Pericentrin antibody; Pericentrin, formerly antibody; Pericentrin-1 antibody; Pericentrin1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NUP85
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis.
  • 基因功能参考文献：
    1. results support a model of CCR2 equilibrium: chemokine binding changes the conformational equilibrium of CCR2 toward the active state, and Pro-C switches its binding partner from the membrane to FROUNT PMID: 25283965
    2. Residues on the hydrophobic side are completely conserved among FROUNT-binding receptors. PMID: 24128342
    3. Data show that the C Terminus of Nup120 Directly Binds Nup145C and Nup85. PMID: 19576787
    4. The CCL2/CCR2 pathway via FROUNT may influence the clinical severity of CHF. PMID: 17395051
    5. FROUNT binds to the C-terminal domain of CCR5 in addition to that of CCR2. PMID: 19841162

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  • 亚细胞定位：
    Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane.
  • 蛋白家族：
    Nucleoporin Nup85 family
  • 数据库链接：

    HGNC: 8734

    OMIM: 170285

    KEGG: hsa:79902

    STRING: 9606.ENSP00000245544

    UniGene: Hs.362817