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NUTF2 Antibody

  • 货号：
    CSB-PA006428
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using NTF2 Polyclonal Antibody
    • Western Blot analysis of Hela cells using NTF2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P61970
  • 基因名：
  • 别名：
    NTF 2 antibody; NTF-2 antibody; NTF2 antibody; NTF2_HUMAN antibody; Nuclear transport factor 2 antibody; Nutf2 antibody; Placental protein 15 antibody; PP15 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NTF2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
  • 基因功能参考文献：
    1. These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase. PMID: 29017749
    2. Binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules. PMID: 26823604
    3. Nucleocytoplasmic translocation of NTF2 is regulated in mammalian cells. PMID: 22880006
    4. Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation. PMID: 21195711
    5. A nuclear pore binding site was studied on a mutated NTF2 protein. PMID: 15522285
    6. Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG. PMID: 18266911
    7. NTF2 is a potential mediator of retinal vasculature integrity. PMID: 19404486

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  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm.
  • 数据库链接：

    HGNC: 13722

    OMIM: 605813

    KEGG: hsa:10204

    STRING: 9606.ENSP00000219169

    UniGene: Hs.356630