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Nid1 Antibody

  • 货号：
    CSB-PA015802LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Nid1 antibody at 6µg/ml + Rat lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 137 kDa
      Observed band size: 150 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Nid1 Polyclonal antibody
  • Uniprot No.：
    P10493
  • 基因名：
    Nid1
  • 别名：
    Nid1 antibody; Ent antibody; Nidogen-1 antibody; NID-1 antibody; Entactin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse, Rat
  • 免疫原：
    Recombinant Mouse Nidogen-1 protein (428-665AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Nid1 Antibody (CSB-PA015802LA01MO)，的标记方式是Non-conjugated。对于Nid1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA015802LB01MO Nid1 Antibody, HRP conjugated ELISA
    FITC CSB-PA015802LC01MO Nid1 Antibody, FITC conjugated
    Biotin CSB-PA015802LD01MO Nid1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.
  • 基因功能参考文献：
    1. Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes. PMID: 25387007
    2. The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation. PMID: 23948589
    3. nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels. PMID: 24280453
    4. finding demonstrates that nidogens, although homologous proteins, exert their effect on BM assembly through different binding domains, which may in turn result in alterations of BM structure and functions PMID: 22623588
    5. show that loss of nidogen 2, but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane PMID: 22260998
    6. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain. PMID: 21084308
    7. This study demonstrates that nidogen-1 is essential for maintenance of normal hippocampal excitability and synaptic plasticity. PMID: 19530222
    8. Results suggest a non-structural role for nidogen 1 in wound repair. PMID: 19766719
    9. Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development. PMID: 12015298
    10. These findings revealed extensive coregulation of nidogen-1 and -2 expression and much more complementary functions of the two nidogens than previously recognized. PMID: 12243745
    11. Three- to sevenfold increase in nidogen-2 was observed in heart and muscle of mice with nidogen-1 deficiency. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. PMID: 12475645
    12. structure of the interacting domains reveals a six-bladed Tyr-Trp-Thr-Asp (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in laminin (LE3-5) PMID: 12931195
    13. Expression may promote formation of sinusoids after partial hepatectomy. PMID: 15777791
    14. Laminin gamma3 chain, located in murine basement membranes, binds to nidogen PMID: 15824114
    15. Nid1 is essential for late stages of lung development and for maintenance and/or integrity of cardiac tissue PMID: 16024816
    16. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
    17. nidogen-1 and -2 have roles in development of the ectodermal basement membrane of the limb bud PMID: 17023412
    18. expression of the entactin-1 dramatically declined in myogenesis PMID: 17177854
    19. The lack of nidogen-1, nidogen-2, or both nidogens, plays no crucial role in the occurrence and localization of laminin-111, collagen type IV, and perlecan in murine tubular renal basement membranes. PMID: 17616934
    20. In capillaries, basement membrane formation is severely impaired in the absence of nidogen-1 and -2, showing an irregular, patchy distribution and a dramatically reduced deposition of collagen IV, perlecan, and particularly laminin-411. PMID: 18356808

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 数据库链接：

    KEGG: mmu:18073

    STRING: 10090.ENSMUSP00000005532

    UniGene: Mm.4691