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Nmdar1 Antibody

  • 货号：
    CSB-PA634509XA01DLU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes: Nmdar1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 34 kDa
      Observed band size: 34 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Drosophila melanogaster (Fruit fly) Nmdar1 Polyclonal antibody
  • Uniprot No.：
    Q24418
  • 基因名：
    Nmdar1
  • 别名：
    Glutamate [NMDA] receptor subunit 1 (DNMDAR-I) (dNR1) Nmdar1 nmr NR1 CG2902
  • 宿主：
    Rabbit
  • 反应种属：
    Drosophila melanogaster (Fruit fly)
  • 免疫原：
    Recombinant Drosophila melanogaster (Fruit fly) Nmdar1 protein (291-573)
  • 免疫原种属：
    Drosophila melanogaster (Fruit fly)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.
  • 基因功能参考文献：
    1. Recent studies indicate that several risk genes for schizophrenia are within two degrees of separation from the N-methy-D-aspartate receptor (NMDAR), a subtype of glutamate receptor that is critical to synapse formation and synaptic plasticity.[review] PMID: 26954593
    2. NMDAR1 promotes sleep regulation in Drosophila. PMID: 26023770
    3. NMDA Receptor 1 plays a role in both behavioral responses to touch and in the formation of the actin-rich sensory filopodia. PMID: 23103192
    4. The study suggested that Mg(2+) block of NMDARs functions to suppress basal expression of a CREB repressor, thus permitting CREB-dependent gene expression upon LTM induction. PMID: 22681692
    5. NMDA receptor (dNR1) mediate associative olfactory learning and memory in Drosophila PMID: 15823532
    6. nmda receptor 1 regiure for long-term memory consolidation in Drosophila ellipsoid body. PMID: 17982450
    7. Distribution of the NR1 subunit of the NMDA receptor in the cerebral ganglia of the honeybee and fruit fly are similar; areas with the highest concentrations of NR1 subunits were identified and compared. PMID: 18401728

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family
  • 组织特异性：
    Highly expressed in adult heads: in the brain and ring gland. Low expression throughout the entire brain is also seen. Higher expression levels were observed in some scattered cell bodies and part of their fibers, including those from several pairs of DPM
  • 数据库链接：

    KEGG: dme:Dmel_CG2902

    STRING: 7227.FBpp0078410

    UniGene: Dm.3670