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OGDH Antibody

  • 货号：
    CSB-PA016307GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q02218
  • 基因名：
    OGDH
  • 别名：
    2 oxoglutarate dehydrogenase antibody; 2 oxoglutarate dehydrogenase complex component E1 antibody; 2 oxoglutarate dehydrogenase mitochondrial antibody; 2-oxoglutarate dehydrogenase antibody; 2-oxoglutarate dehydrogenase complex component E1 antibody; AKGDH antibody; Alpha ketoglutarate dehydrogenase antibody; Alpha-ketoglutarate dehydrogenase antibody; E1k antibody; mitochondrial antibody; ODO1_HUMAN antibody; OGDC antibody; OGDC E1 antibody; OGDC-E1 antibody; OGDH antibody; Oxoglutarate (alpha ketoglutarate) dehydrogenase (lipoamide) antibody; Oxoglutarate decarboxylase antibody; Oxoglutarate dehydrogenase (lipoamide) antibody; Oxoglutarate dehydrogenase (succinyl transferring) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OGDH
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
  • 基因功能参考文献：
    1. PIK3CA mutant cancer cells require PIK3CA but also require the expression of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH). PMID: 28396387
    2. oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS), which when mutated stabilize HIF1alpha in a non-hydroxylated form. PMID: 27923773
    3. Tissue-specific expression of OGDH splice variants may thus provide a mechanism that tunes the control of the enzyme to the specialized metabolic and signalling needs of individual cell types PMID: 26936970
    4. ATP consumption is demonstrated in respiration-impaired isolated mice and in situ neuronal mitochondria from transgenic mice with dihydrolipoyl succinyltransferase deficiency. PMID: 23475850
    5. Acute inhibition of alpha-ketoglutarate dehydrogenase produces effects on calcium opposite to those in Alzheimer's disease (AD), while the chronic or long-term inhibition of alpha-KGDHC mimicked the AD-related changes in calcium. PMID: 22169199
    6. Differences in oxoglutarate dehydrogenase activity suggest that there is no excess mitochondrial capacity during maximal exercise with a small muscle mass. PMID: 21611730
    7. 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability is regulated by the RING finger ubiquitin ligase Siah PMID: 15466852
    8. Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. PMID: 15649899
    9. Association with autosomal recessive DOOR syndrome not found. PMID: 17343268

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  • 亚细胞定位：
    Mitochondrion matrix. Nucleus.
  • 蛋白家族：
    Alpha-ketoglutarate dehydrogenase family
  • 数据库链接：

    HGNC: 8124

    OMIM: 613022

    KEGG: hsa:4967

    STRING: 9606.ENSP00000222673

    UniGene: Hs.488181