Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. OLA1 Antibody

OLA1 Antibody

  • 货号：
    CSB-PA016318GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NTK5
  • 基因名：
    OLA1
  • 别名：
    DKFZp313H1942 antibody; DNA damage-regulated overexpressed in cancer 45 protein antibody; DOC45 antibody; EC 3.6.3 antibody; GBP45 antibody; GTP-binding protein 9 (putative) antibody; GTP-binding protein 9 antibody; GTP-binding protein PTD004 antibody; homologous yeast-44.2 protein antibody; Obg like ATPase 1 antibody; Obg-like ATPase 1 antibody; OLA1 antibody; OLA1_HUMAN antibody; PTD004 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OLA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
  • 基因功能参考文献：
    1. No germline mutations were found in the OLA1 gene in in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer. PMID: 27271530
    2. OLA1 contributes to epithelial-mesenchymal transition by modulating the GSK3beta/Snail/E-cadherin signaling, and its overexpression is associated with clinical progression and poor survival in lung cancer patients. PMID: 26863455
    3. Our work suggests that OLA1 is a novel translational GTPase and plays a suppressive role in translation and cell survival, as well as cancer growth and progression. PMID: 26283179
    4. OLA1 plays an important negative role in cell adhesion and spreading, in part through the regulation of FAK expression and cofilin phosphorylation, and manipulation of OLA1 may lead to significant changes in cell adhesion and the associated phenotypes. PMID: 24486488
    5. OLA1 plays an important role in centrosome regulation together with BRCA1. PMID: 24289923
    6. Downregulation of OLA1 in mammalian cells by either RNAi or targeted gene disruption results in reduced steady-state levels of HSP70, impaired HSP70 induction by heat, and functionally, increased cellular sensitivity to heat shock. PMID: 23412384
    7. DOC45 is a novel ATPase that is linked to cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. PMID: 20053727
    8. knockdown of OLA1 inhibits breast cancer cell migration and invasion through a mechanism that involves the modulation of intracellular ROS levels PMID: 19882753
    9. Results indicate that Gbp45/OLA1 plays important roles in cell proliferation and death related to mitochondrial function. PMID: 18536999
    10. OLA1 suppresses the antioxidant response through nontranscriptional mechanisms. PMID: 19706404

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, YchF/OLA1 subfamily
  • 组织特异性：
    Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.
  • 数据库链接：

    HGNC: 28833

    OMIM: 611175

    KEGG: hsa:29789

    STRING: 9606.ENSP00000284719

    UniGene: Hs.157351