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  4. OLFM1 Antibody

OLFM1 Antibody

  • 货号：
    CSB-PA110084
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA110084(OLFM1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA110084(OLFM1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q99784
  • 基因名：
    OLFM1
  • 别名：
    AMY antibody; NEUROBLASTOMA PROTEIN antibody; Neuronal olfactomedin-related ER localized protein antibody; Noe1 antibody; NOE1_HUMAN antibody; Noel antibody; Noel1 antibody; Noelin antibody; Noelin1 antibody; OlfA antibody; Olfactomedin 1 antibody; Olfactomedin-1 antibody; Olfm1 antibody; Pancortin 1 antibody; Pancortin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human OLFM1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse. May play an important role in regulating the production of neural crest cells by the neural tube. May be required for normal responses to olfactory stimuli.
  • 基因功能参考文献：
    1. OLFM1 is a negative regulator of non-canonical NF-kappaB signalling by interacting with and inhibiting NIK. Thus, OLFM1 may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC) patients. PMID: 27555280
    2. human chorionic gonadotropin stimulated miR-212, which down-regulated OLFM1 and CTBP1 expression in fallopian and endometrial epithelial cells to favor spheroid attachment PMID: 26377223
    3. OLF domains from H. sapiens olfactomedin-1 and M. musculus gliomedin were biophysically, biochemically, and structurally characterized. PMID: 26121352
    4. Down-regulation of OLFM1 in fallopian tube epithelial cells enhances spheroid attachment to fallopian tube. PMID: 25999259
    5. Wnt activation suppresses Olfm-1 expression, and this may predispose a favorable microenvironment of the retained embryo in the Fallopian tube, leading to ectopic pregnancy in humans PMID: 21968811

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  • 亚细胞定位：
    Secreted. Cell junction, synapse. Endoplasmic reticulum. Cell projection, axon. Perikaryon.
  • 数据库链接：

    HGNC: 17187

    OMIM: 605366

    KEGG: hsa:10439

    STRING: 9606.ENSP00000252854

    UniGene: Hs.522484