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OLFM2 Antibody

  • 货号：
    CSB-PA016321GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O95897
  • 基因名：
    OLFM2
  • 别名：
    Neuronal olfactomedin related ER localized protein 2 antibody; NOE2 antibody; NOE2_HUMAN antibody; Noelin 2 antibody; Noelin-2 antibody; NOELIN2 antibody; NOELIN2 V1 antibody; Olfactomedin 2 antibody; Olfactomedin-2 antibody; OlfC antibody; Olfm2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OLFM2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling.
  • 基因功能参考文献：
    1. plasma OLFM2 is a potential biomarker for restenosis and may be a novel target for the treatment of restenosis. PMID: 29553861
    2. Our study indicates that OLFM2 is likely to be important in mammalian eye development and disease and should be considered as a gene for human ocular anomalies. PMID: 27844144
    3. Olfm2 physically interacts with serum response factor (SRF) without affecting the SRF-myocardin interaction. PMID: 25298399
    4. The Arg144Gln mutation in OLFM2 is a possible disease-causing mutation in Japanese patients with OAG. Common polymorphisms in OLFM2 and OPTN may interactively contribute to the development of OAG, indicating a polygenic etiology. PMID: 17122126
  • 亚细胞定位：
    Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm.
  • 组织特异性：
    Expressed in aortic smooth muscle (at protein level). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup.
  • 数据库链接：

    HGNC: 17189

    OMIM: 617492

    KEGG: hsa:93145

    STRING: 9606.ENSP00000264833

    UniGene: Hs.169743