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ONECUT2 Antibody

  • 货号：
    CSB-PA016337LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate
      All lanes: ONECUT2 antibody at 2.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 55 kDa
      Observed band size: 55 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA016337LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    ONECUT2 antibody CSB-PA016337LA01HU was produced in the rabbits immunized by using the recombinant human ONECUT2 protein (214-331aa) as the immunogen. The target protein ONECUT2 mainly regulates gene expression in various tissues, playing a crucial role in the development, differentiation, and cellular processes critical for proper physiological function. Aberrant expression or activity of ONECUT2 has been implicated in various diseases, including diabetes, liver disease, and neurodevelopmental disorders.

    This rabbit anti-human ONECUT2 polyclonal antibody was quality tested in the ELISA, WB, and IHC applications. The non-conjugated IgG got purified by protein G and reached up to 95% in purity. It only reacts with the ONECUT2 proteins from human samples.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ONECUT2 Polyclonal antibody
  • Uniprot No.：
    O95948
  • 基因名：
    ONECUT2
  • 别名：
    ONECUT2 antibody; HNF6B antibody; One cut domain family member 2 antibody; Hepatocyte nuclear factor 6-beta antibody; HNF-6-beta antibody; One cut homeobox 2 antibody; Transcription factor ONECUT-2 antibody; OC-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human One cut domain family member 2 protein (214-331AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ONECUT2 Antibody (CSB-PA016337LA01HU)，的标记方式是Non-conjugated。对于ONECUT2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA016337LB01HU ONECUT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA016337LC01HU ONECUT2 Antibody, FITC conjugated
    Biotin CSB-PA016337LD01HU ONECUT2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
  • 基因功能参考文献：
    1. Bioinformatics-based prediction, combined with qRT-PCR analysis and Western blotting, identified Onecut2 and SIRT1 as the 2 prominent miR-9 target genes under the conditions tested. In this study, Onecut2 and SIRT1 were confirmed as miR-9 target genes, which will help future investigations to probe in greater detail the role of miR-9 in Nonalcoholic Fatty Liver Disease. PMID: 27756894
    2. Data show that ONECUT2, IGF2BP1, and ANXA2 proteins were confirmed to be microRNA-9 (miR-9) targets and aberrantly upregulated in hepatocellular carcinoma (HCC). PMID: 26547929
    3. our data showed that transcript factor Onecut2 is involved in the EMT, migration and invasion of CRC cells; miR-429 inhibits the initiation of EMT and regulated expression of EMT-related markers PMID: 24402783
    4. Mutations at the -5/-6 site of the F9 promotor account for the majority of hemophilia B Leyden cases and disrupt the binding of ONECUT1 and ONECUT2. PMID: 23472758
    5. OC2 transcription factor is a direct target of T-bet in type-1 T-helper cells. PMID: 18418398
    6. A CpG island proximal to ONECUT2 is frequently methylated in diffuse large B-cell lymphoma (DLBCL). PMID: 18288132

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CUT homeobox family
  • 数据库链接：

    HGNC: 8139

    OMIM: 604894

    KEGG: hsa:9480

    STRING: 9606.ENSP00000262095

    UniGene: Hs.194725