Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ORAOV1 Antibody

ORAOV1 Antibody

  • 货号：
    CSB-PA003600
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using ORAOV1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8WV07
  • 基因名：
    ORAOV1
  • 别名：
    LTO1 antibody; ORAOV1 antibody; TAOS1Protein LTO1 homolog antibody; Oral cancer-overexpressed protein 1 antibody; Tumor-amplified and overexpressed sequence 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ORAOV1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. May play a role in the regulation of proline metabolism and ROS production.
  • 基因功能参考文献：
    1. provides the first evidence of ORAOV1 overexpression in esophageal squamous cell cancer and esophageal squamous intraepithelial neoplasia PMID: 25732110
    2. the ORAOV1 gene is frequently amplified in esophageal squamous cell cancer PMID: 24930674
    3. The ORAOV1 complex could prevent ROS-induced ribosomal damage, explaining why overexpression of ORAOV1 is so common in solid tumours PMID: 23318452
    4. overexpression of ORAOV1 in non-tumoral margin samples can occur in absence of amplification. weak correlation between ORAOV1 amplification and expression in OSSC suggests ORAOV1 expression can be regulated by mechanisms other than gene amplification. PMID: 21623924
    5. An oral cancer overexpressed 1 (ORAOV1) gene was identified as a probable target within the 11q13 amplicon in lymph node metastases from gastric adenocarcinoma. PMID: 21993861
    6. ORAOV1 has an important role in regulating cell growth of cervical cancer HeLa cells through regulating the cell cycle and apoptosis. PMID: 20105337
    7. High-resolution mapping of the 11q13 amplicon and identification of a gene that is amplified and overexpressed in oral cancer cells PMID: 12172009
    8. data suggested potential roles in oral carcinogenesis and that TAOS1 might be involved earlier than EMS1. Both genes might be candidate biomarkers for diagnosis and prognosis in OSCC PMID: 17005439
    9. ORAOV1 plays pivotal roles in the growth and angiogenesis of oral squamous cell carcinoma. PMID: 18688849
    10. In OSCC tissue samples, the expression frequency of ORAOV1-A (51.1%) was much higher than that in normal samples (10.5%). ORAOV1-A may play a functional role in the tumorigenesis of OSCC. PMID: 19493886

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ORAOV1 family
  • 组织特异性：
    Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.
  • 数据库链接：

    HGNC: 17589

    OMIM: 607224

    KEGG: hsa:220064

    STRING: 9606.ENSP00000279147

    UniGene: Hs.667996