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OSBPL10 Antibody

  • 中文名称：
    OSBPL10兔多克隆抗体
  • 货号：
    CSB-PA017245GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BXB5
  • 基因名：
    OSBPL10
  • 别名：
    FLJ20363 antibody; ORP-10 antibody; ORP10 antibody; OSB10_HUMAN antibody; OSBP related protein 10 antibody; OSBP-related protein 10 antibody; OSBP9 antibody; OSBPL 10 antibody; OSBPL10 antibody; Oxysterol binding protein like 10 antibody; Oxysterol binding protein related protein 10 antibody; Oxysterol-binding protein-related protein 10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OSBPL10
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.
  • 基因功能参考文献：
    1. Data indicate that the apoB-100 secretion phenotype is replicated in HepG2 cells transduced with the ORP10 shRNA lentiviruses. PMID: 22906437
    2. Single-nucleotide polymorphisms in OSBPL10 is associated with peripheral arterial disease. PMID: 20610895
    3. Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals to hyper-LDL cholesterolemia. PMID: 20224571
    4. Analysis of variants in three genes encoding OSBP homologues in families with familial low high-density lipoprotein levels or familial combined hyperlipidemia revealed linkage of OSBPL10 single-nucleotide polymorphisms with high triglyceride trait. PMID: 19554302
  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    OSBP family
  • 数据库链接：

    HGNC: 16395

    OMIM: 606738

    KEGG: hsa:114884

    STRING: 9606.ENSP00000379804

    UniGene: Hs.150122