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OSBPL2 Antibody

  • 货号：
    CSB-PA884442LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: OSBPL2 antibody at 1μg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Mouse heart tissue
      Lane 3: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 54 kDa
      Observed band size: 56 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA884442LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) OSBPL2 Polyclonal antibody
  • Uniprot No.：
    Q9H1P3
  • 基因名：
    OSBPL2
  • 别名：
    FLJ20223 antibody; KIAA0772 antibody; MGC4307 antibody; MGC8342 antibody; ORP-2 antibody; ORP2 antibody; OSBL2_HUMAN antibody; OSBP related protein 2 antibody; OSBP-related protein 2 antibody; OSBPL2 antibody; Oxysterol binding protein like 2 antibody; Oxysterol binding protein related protein 2 antibody; Oxysterol-binding protein-related protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Oxysterol-binding protein-related protein 2 protein (251-480AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，OSBPL2 Antibody (CSB-PA884442LA01HU)，的标记方式是Non-conjugated。对于OSBPL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA884442LB01HU OSBPL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA884442LC01HU OSBPL2 Antibody, FITC conjugated
    Biotin CSB-PA884442LD01HU OSBPL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro).
  • 基因功能参考文献：
    1. point at a novel function of ORP2 as a lipid-sensing regulator of the actin cytoskeleton, with impacts on hepatocellular migration, adhesion, and proliferation PMID: 29092904
    2. this study identifies ORP2 as a new regulatory nexus of Akt signaling, cellular energy metabolism, actin cytoskeletal function, cell migration, and proliferation. PMID: 29947926
    3. a novel role for ORP2 in regulating steroidogenic capacity and cholesterol homeostasis in the adrenal cortex PMID: 26992564
    4. This study and the recent description of another frameshift mutation in a Chinese ADNSHL family identify OSBPL2 as a novel gene for progressive deafness. PMID: 25759012
    5. Results identified frameshift and missense mutation in OSBPL2 gene in familial and sporadic case of deafness suggesting OSBPL2 as a novel candidate gene for autosomal dominant nonsyndromic hearing loss . PMID: 25077649
    6. ORP2 as a novel regulator of cellular sterol homeostasis and intracellular membrane trafficking. PMID: 11861666
    7. Results identify ORP2 as a sterol receptor present on LD and provide evidence for its role in the regulation of neutral lipid metabolism, possibly as a factor that integrates the cellular metabolism of triglycerides with that of cholesterol. PMID: 19224871

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  • 相关疾病：
    Deafness, autosomal dominant, 67 (DFNA67)
  • 亚细胞定位：
    Cytoplasm, cytosol. Lipid droplet. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    OSBP family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 15761

    OMIM: 606731

    KEGG: hsa:9885

    STRING: 9606.ENSP00000316649

    UniGene: Hs.473254