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P4HTM Antibody

  • 货号：
    CSB-PA878913LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) P4HTM Polyclonal antibody
  • Uniprot No.：
    Q9NXG6
  • 基因名：
    P4HTM
  • 别名：
    EGLN4 antibody; HIF PH4 antibody; HIF Prolyl Hydroxylase 4 antibody; HIF prolyl hydroxylase PH 4 antibody; HIF prolyl hydroxylase PH4 antibody; HIF-PH4 antibody; HIF-prolyl hydroxylase 4 antibody; HIFPH4 antibody; HPH 4 antibody; HPH-4 antibody; Hypoxia inducible factor prolyl 4 hydroxylase antibody; Hypoxia-inducible factor prolyl hydroxylase 4 antibody; P4H with transmembrane domain antibody; P4H-TM antibody; P4htm antibody; P4HTM_HUMAN antibody; PH 4 antibody; PH4 antibody; PHD 4 antibody; Proline 4 hydroxylase antibody; prolyl 4-hydroxylase antibody; Transmembrane prolyl 4-hydroxylase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transmembrane prolyl 4-hydroxylase protein (82-563AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，P4HTM Antibody (CSB-PA878913LA01HU)，的标记方式是Non-conjugated。对于P4HTM Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA878913LB01HU P4HTM Antibody, HRP conjugated ELISA
    FITC CSB-PA878913LC01HU P4HTM Antibody, FITC conjugated
    Biotin CSB-PA878913LD01HU P4HTM Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
  • 基因功能参考文献：
    1. The results suggest that SESN2 increases degradation of HIF-1A via AMPK-PHD regulation that contributes to inhibition of in vitro and in vivo tumorigenesis. PMID: 27840318
    2. This review will expand our knowledge of biology of HIFs, PHDs, PHD inhibitors, and bone regeneration, and it may also aid the design of novel therapies for accelerating bone repair and regeneration or inhibiting bone tumours. [review] PMID: 24895555
    3. Results suggest that increased expression of prolyl hydroxylase (PH) might play an role in the physiology of uterine leiomyoma during the menstrual cycle. PMID: 23241241
    4. Data suggest that PH-4 is a novel hypoxia-inducible factor-prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. PMID: 12163023
    5. the longest and shortest isoenzymes have major transcripts encoding inactive polypeptides, which suggest novel regulation by alternative splicing. PMID: 12788921
    6. crystal structure of the peptide-substrate-binding domain PMID: 15456751
    7. This review summarizes recent progress in elucidating the molecular mechanisms of hypoxia-inducible factor (HIF)-1 activation, focusing on the role of oxygen-dependent asparaginyl hydroxylase in hypoxia signal transduction. PMID: 16154531

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts.
  • 数据库链接：

    HGNC: 28858

    OMIM: 614584

    KEGG: hsa:54681

    STRING: 9606.ENSP00000341422

    UniGene: Hs.654944