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PACS2 Antibody

  • 货号：
    CSB-PA017372GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q86VP3
  • 基因名：
    PACS2
  • 别名：
    6720425G15Rik antibody; AW208651 antibody; AW489976 antibody; E230011J22 antibody; FLJ25488 antibody; KIAA0602 antibody; mKIAA0602 antibody; PACS 2 antibody; PACS-2 antibody; PACS1 like protein antibody; PACS1-like protein antibody; PACS1L antibody; PACS2 antibody; PACS2_HUMAN antibody; Phosphofurin acidic cluster sorting protein 1 like antibody; Phosphofurin acidic cluster sorting protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PACS2-Specific
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
  • 基因功能参考文献：
    1. These findings support the causality of this recurrent de novo PACS2 heterozygous missense in Developmental and epileptic encephalopathies with facial dysmorphim and cerebellar dysgenesis. PMID: 29656858
    2. Protein adaptation and the expanding roles of the PACS1 and PACS2 proteins in tissue homeostasis and disease has been summarized. (Review) PMID: 28476937
    3. Missense Mutation in PACS2 gene is associated with Neurodevelopmental Disorders. PMID: 28867141
    4. cIAPs constitutively downregulate PACS-2 by polyubiquitination and proteasomal degradation, thereby restraining TRAIL-induced killing of liver cancer cells PMID: 24633224
    5. The sites on Nef and the PACS proteins required for their interaction, are identified. PMID: 22496420
    6. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2. PMID: 22645134
    7. subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2 PMID: 15692563
    8. PACS-2 as a novel sorting protein that links the endoplasmic reticulum (ER)-mitochondria axis to ER homeostasis PMID: 15692567
    9. PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system PMID: 18296443
    10. the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort the chaperone between domains of the ER and the plasma membrane PMID: 18417615
    11. Results identify PACS-2 as an essential TRAIL effector, and show that Akt cooperates with 14-3-3 to regulate the homeostatic and apoptotic properties of PACS-2 that mediate TRAIL action. PMID: 19481529

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  • 亚细胞定位：
    Endoplasmic reticulum. Mitochondrion.
  • 蛋白家族：
    PACS family
  • 组织特异性：
    Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.
  • 数据库链接：

    HGNC: 23794

    OMIM: 610423

    KEGG: hsa:23241

    STRING: 9606.ENSP00000393559

    UniGene: Hs.525626