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PAG1 Antibody

  • 货号：
    CSB-PA885746LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA885746LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA885746LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA885746LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse heart tissue, Mouse lung tissue
      All lanes: PAG1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47 kDa
      Observed band size: 47 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PAG1 Polyclonal antibody
  • Uniprot No.：
    Q9NWQ8
  • 基因名：
    PAG1
  • 别名：
    CBP antibody; Csk binding protein antibody; Csk-binding protein antibody; FLJ37858 antibody; MGC138364 antibody; PAG 1 antibody; PAG antibody; PAG1 antibody; PAG1_HUMAN antibody; Phosphoprotein associated with glycosphingolipid enriched microdomains 1 antibody; Phosphoprotein associated with glycosphingolipid enriched microdomains antibody; Phosphoprotein associated with glycosphingolipid microdomains 1 antibody; Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 antibody; Protein Associated with Glycosphingolipid Enriched Microdomains antibody; Transmembrane adapter protein PAG antibody; Transmembrane phosphoprotein Cbp antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 protein (97-432AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PAG1 Antibody (CSB-PA885746LA01HU)，的标记方式是Non-conjugated。对于PAG1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA885746LB01HU PAG1 Antibody, HRP conjugated ELISA
    FITC CSB-PA885746LC01HU PAG1 Antibody, FITC conjugated
    Biotin CSB-PA885746LD01HU PAG1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
  • 基因功能参考文献：
    1. Low PAG1 expression is associated neuroblastoma. PMID: 26993602
    2. Our study highlights the underlying mechanism of cross interaction between ASCs and breast cancer cells, and indicates that PAG1/Cbp in breast cancer cell may modulate tumor progression and acquired chemoresistance in the ASCs-associated breast cancer microenvironment through Src and AKT/mTOR pathways. PMID: 29079189
    3. Up-regulated expression of CBP in Jurkat cells could reduce cell homogeneity and promote cell apoptosis PMID: 26062415
    4. No association Pag1 mutation with patient with Schizophrenia. PMID: 25005592
    5. The risk-associated allele of rs2370615 predisposes to allergic disease by increasing PAG1 expression, which might promote B cell activation and have a pro-inflammatory effect. PMID: 26211970
    6. CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. PMID: 25684946
    7. The inhibitory function of novobiocin in disrupting the HIF1alpha/p300 complex might be important in tumor cell growth. PMID: 23671581
    8. siRNA directed against PAG1 in a radioresistant (Hep-2max) cell line dramatically enhanced the radiosensitivity and IR-induced cell death. PMID: 22994656
    9. expression of CBP gene is decreased in esophageal carcinoma, which might contribute to the tumorigenesis and progression. PMID: 22027792
    10. findings support a negative regulatory function for Cbp/PAG in proximal B cell receptor signaling in normal and EBV-transformed B cells PMID: 22659621
    11. An over-expression of PAG1 in PC-3M-1E8 cells effectively suppresses the activation of Ras and ERK, as well as the cyclin D1 expression, leading to an inhibition of the proliferation ability of tumor cells. PMID: 21092590
    12. Cbp down-regulation is primarily mediated by epigenetic histone modifications via oncogenic MAPK/PI3K pathways in a subset of cancer cells. PMID: 21388951
    13. Results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation. PMID: 21156787
    14. PAG1 protein was downregulated in PC-3M-1E8 prostate cancer cell line. PMID: 20388373
    15. In the membrane environment of ALK+ lymphoma rafts, where the glycosphingolipid to signaling protein ratio is higher than in B-NHL rafts, the Lyn activity is suboptimal and does not allow the formation of an efficient Lyn-Cbp/PAG signalosome PMID: 20561033
    16. Study shows EGF-stimulation-induced Csk-binding protein (Cbp) tyrosine phosphorylation followed by Cbp-Csk association, in a SFK-dependent manner. PMID: 16636672
    17. High PAG-binding ability with CSK in vitro as well as the human PAG structure characterized by 11 alpha-helix structures including a 3 kDa transmembrane domain are reported. PMID: 16947079
    18. PAG negatively regulates Ras proteins, and by knocking down PAG there is enhanced Src kinase activity and Ras activation. PMID: 17389760
    19. engagement of the SH2 domain on PAG renders FynT insensitive to Csk negative regulation PMID: 18056706
    20. role in control of proliferation and survival in most B-non-Hodgkin lymphomas PMID: 18070987
    21. new insights into the function of Cbp in modulating RhoA activation, by which Cbp might contribute to renal cell carcinogenesis PMID: 19581936

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  • 亚细胞定位：
    Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
  • 组织特异性：
    Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
  • 数据库链接：

    HGNC: 30043

    OMIM: 605767

    KEGG: hsa:55824

    STRING: 9606.ENSP00000220597

    UniGene: Hs.266175