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PAIP2 Antibody

  • 货号：
    CSB-PA859027LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, SH-SY5Y whole cell lysate, HEK293 whole cell lysate, Mouse lung tissue, Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue
      All lanes: PAIP2 antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 15 kDa
      Observed band size: 15 kDa
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA859027LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA859027LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PAIP2 Polyclonal antibody
  • Uniprot No.：
    Q9BPZ3
  • 基因名：
    PAIP2
  • 别名：
    PABP-interacting protein 2 antibody; PAIP-2 antibody; PAIP2 antibody; PAIP2_HUMAN antibody; poly(A) binding protein interacting protein 2 antibody; Poly(A)-binding protein-interacting protein 2 antibody; Polyadenylate-binding protein-interacting protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Polyadenylate-binding protein-interacting protein 2 protein (1-127AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PAIP2 Antibody (CSB-PA859027LA01HU)，的标记方式是Non-conjugated。对于PAIP2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA859027LB01HU PAIP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA859027LC01HU PAIP2 Antibody, FITC conjugated
    Biotin CSB-PA859027LD01HU PAIP2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
  • 基因功能参考文献：
    1. Paip2 is a host antiviral restriction factor antagonized by PABP accumulation in HCMV-infected cells PMID: 23964095
    2. Role of PAIP2 in modulation of GLUT5 mRNA stability. PMID: 12820898
    3. PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis PMID: 15175342
    4. The turnover of Paip2 in the cell is mediated by EDD and is regulated by PABP. PMID: 16601676
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    PAIP2 family
  • 组织特异性：
    Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.
  • 数据库链接：

    HGNC: 17970

    OMIM: 605604

    KEGG: hsa:51247

    STRING: 9606.ENSP00000265192

    UniGene: Hs.396644