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PALLD Antibody

  • 货号：
    CSB-PA011060
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8WX93
  • 基因名：
    PALLD
  • 别名：
    PALLD antibody; KIAA0992 antibody; CGI-151Palladin antibody; SIH002 antibody; Sarcoma antigen NY-SAR-77 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Palladin.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.
  • 基因功能参考文献：
    1. Twist1 appears to require both palladin and collagen alpha1(VI) as downstream effectors for its prometastatic effects, which could be future therapeutic targets in cancer metastasis. PMID: 26973246
    2. Palladin role in the vascular smooth muscle cell differentiation and gene expression PMID: 27088725
    3. stromal palladin expression is a surrogate indicator of the treatment effect after chemoradiation therapy. PMID: 27023252
    4. Study identified the actin-associated protein palladin as a key node in signaling pathways that result in fibroblast activation in the increased tissue stiffness of a tumor microenvironment PMID: 26200861
    5. Palladin interacts with MT1-MMP to promote tumor cell invasion in breast carcinoma. PMID: 24989798
    6. palladin functions as a dynamic scaffolding protein that promotes the assembly of dorsal stress fibers by recruiting VASP to these structures. PMID: 24496446
    7. Palladin seems to regulate podosome and invodopodia formation through Rho GTPases. [Review] PMID: 24525547
    8. A model whereby palladin-activated fibroblasts facilitate stromal-dependent metastasis and outgrowth of tumorigenic epithelium. PMID: 22291919
    9. results indicate that palladin phosphorylation by ERK has an anti-migratory function, possibly by modulating interactions with molecules that regulate cell migration PMID: 22216253
    10. Observations support the belief that stromal palladin assessments have clinical relevance thus validating the use of these 3D cultures to study both progressive RCC-associated stroma and stroma-dependent mechanisms affecting tumorigenesis. PMID: 21738681
    11. Palladin may identify primary pancreatic endocrine neoplasms with a propensity to metastasize to the liver PMID: 21868544
    12. these results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis. PMID: 21782789
    13. The A-allele of PALLD rs7439293 was not associated with progressive carotid atherosclerosis PMID: 21054356
    14. upregulation of 85-90 kDa palladin isoform may play a role in the establishment of the tumor-associated fibroblasts phenotype, and thus in the formation of a desmoplastic tumor microenvironment PMID: 20436683
    15. Akt signaling regulates the stability of palladin PMID: 21050850
    16. Palladin is an integral component of adherens junctions and plays a role in the localization of E-cadherin to the junctions. The loss of palladin may be an integral part of EMT, an early step in the metastatic spread of colon carcinoma. PMID: 20811713
    17. Akt1 phosphorylates palladin, inducing cytoskeletal reorganization and inhibiting the migration of breast cancer cells. PMID: 20471940
    18. Quantitative analysis of erythrocyte membrane proteins revealed decrease in palladin from patients with homozygous and heterozygous forms of beta-thalassemia. PMID: 15310273
    19. Our results suggest that palladin may play an important role in recruiting profilin to sites of actin dynamics. PMID: 16367745
    20. These results identify palladin 4Ig as a novel marker of myofibroblast conversion in vitro and in vivo. PMID: 16794588
    21. Study identifies palladin as the mutated gene in the pancreatic cancer susceptibility locus at 4q32-34 and validates abnormal expression of the gene in a famililal pancreatic cancer kindred. PMID: 17194196
    22. Palladin RNA was overexpressed in the tissues from precancerous dysplasia and pancreatic adenocarcinoma in both the familial and the sporadic disease. PMID: 17228136
    23. The function of LPP and palladin is context dependent, that they play a critical role in cytoskeletal remodeling, respond to signals induced by vascular injury as well as signals that induce smooth muscle cell hypertrophy, such as angiotension II. PMID: 17322171
    24. Study concludes that the P239S variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer. PMID: 17415588
    25. PALLD was differentially expressed in sclerotic hippocampi compared to non-sclerotic ones. PMID: 17515952
    26. The interplay between palladin, SPIN90 and Src and characterized the role of palladin and SPIN90 in platelet derived growth factor and Src-induced cytoskeletal remodeling, was analyzed. PMID: 17537434
    27. Palladin was up-regulated in adipose-derived adult stem cells during osteogenic differentiation and cyclic tensile strain. PMID: 17687002
    28. palladin overexpression contributes to the invasive behavior of metastatic cells. PMID: 18978809
    29. expression of LPP and palladin are modulated by a mix of mechanical cues, oxidative stress and substrate composition which translate into their up or down regulation in vessel wall injury and early atherogenesis. PMID: 19205907
    30. Single nucleotide polymorphisms in palladin is not associated with pancreatic cancer. PMID: 19336541

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  • 相关疾病：
    Pancreatic cancer 1 (PNCA1)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, myofibril, sarcomere, Z line. Cell projection, ruffle. Cell projection, podosome. Cell projection, lamellipodium. Cell projection, axon. Cell projection, growth cone.
  • 蛋白家族：
    Myotilin/palladin family
  • 组织特异性：
    Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT
  • 数据库链接：

    HGNC: 17068

    OMIM: 606856

    KEGG: hsa:23022

    STRING: 9606.ENSP00000425556

    UniGene: Hs.151220