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PAN2 Antibody

  • 货号：
    CSB-PA017419GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q504Q3
  • 基因名：
    PAN2
  • 别名：
    hPan2 antibody; Inactive ubiquitin carboxyl terminal hydrolase 52 antibody; Inactive ubiquitin carboxyl-terminal hydrolase 52 antibody; KIAA0710 antibody; PAB dependent poly(A) specific ribonuclease subunit 2 antibody; PAB-dependent poly(A)-specific ribonuclease subunit 2 antibody; PABP dependent poly(A) nuclease 2 antibody; PAN 2 antibody; PAN2 antibody; PAN2 homolog PABP1 dependent poly A specific ribonuclease subunit antibody; PAN2 poly(A) specific ribonuclease subunit homolog antibody; PAN2 polyA specific ribonuclease subunit homolog antibody; PAN2_HUMAN antibody; Ubiquitin specific peptidase 52 antibody; Ubiquitin specific protease 52 antibody; USP 52 antibody; USP52 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PAN2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
  • 基因功能参考文献：
    1. USP52 is a bona fide ubiquitin-specific protease, and USP52 promotes ASF1A deubiquitination and stabilization. PMID: 29599486
    2. USP52 is a key component of P-bodies required to prevent HIF1A mRNA degradation PMID: 23398456
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    4. hPan2 and hPan3 have roles in mRNA decay and exhibit cytoplasmic co-localization PMID: 14583602
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, P-body. Nucleus.
  • 蛋白家族：
    Peptidase C19 family, PAN2 subfamily
  • 数据库链接：

    HGNC: 20074

    OMIM: 617447

    KEGG: hsa:9924

    STRING: 9606.ENSP00000401721

    UniGene: Hs.273397