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PAPSS2 Antibody

  • 货号：
    CSB-PA527262LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA527262LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PAPSS2 Polyclonal antibody
  • Uniprot No.：
    O95340
  • 基因名：
    PAPSS2
  • 别名：
    PAPSS2 antibody; ATPSK2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 antibody; PAPS synthase 2 antibody; PAPSS 2 antibody; Sulfurylase kinase 2 antibody; SK 2 antibody; SK2) [Includes: Sulfate adenylyltransferase antibody; EC 2.7.7.4 antibody; ATP-sulfurylase antibody; Sulfate adenylate transferase antibody; SAT); Adenylyl-sulfate kinase antibody; EC 2.7.1.25 antibody; 3'-phosphoadenosine-5'-phosphosulfate synthase antibody; APS kinase antibody; Adenosine-5'-phosphosulfate 3'-phosphotransferase antibody; Adenylylsulfate 3'-phosphotransferase)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Bifunctional 3\'-phosphoadenosine 5\'-phosphosulfate synthase 2 protein (2-138AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PAPSS2 Antibody (CSB-PA527262LA01HU)，的标记方式是Non-conjugated。对于PAPSS2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA527262LB01HU PAPSS2 Antibody, HRP conjugated ELISA
    FITC CSB-PA527262LC01HU PAPSS2 Antibody, FITC conjugated
    Biotin CSB-PA527262LD01HU PAPSS2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases. In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. Plays indirectly an important role in skeletogenesis during postnatal growth.
  • 基因功能参考文献：
    1. In an Amish population, using expression profiling of genes within regions identified by a meta-analysis GWAS of survival to age 90, we localized PAPSS2 as a candidate gene for extended life span. These results provide novel evidence for genetic loci implicated in longevity and incorporate gene expression results from a unique population to locate positional candidates. PMID: 26896383
    2. Silencing of SULT1A1 and PAPSS2 led to a significant decrease in aristolactam-DNA levels in both cell lines following exposure to AA-I, indicating the critical role for sulfonation in the activation of AA-I in vivo Since HK-2 cells proved relatively resistant to knockdown with siRNAs PMID: 27207664
    3. Our results indicate that FGFR2 and PAPSS2 may play an important role in the regulation of magnesium homeostasis in children of European-American ancestry. PMID: 26685716
    4. Results suggest that the loss of the susceptible region on chromosome 10q, which implicates PTEN, FAS and PAPSS2 may serve as genetic predictors of PSA recurrence after radical prostatectomy. PMID: 25679447
    5. Direct in vivo evidence for the significant functional impact of mutant PAPSS2 on DHEA sulfation and androgen activation. PMID: 25594860
    6. PAPSS2-brachyolmia includes phenotypes of the conventional clinical concept of brachyolmia, the Hobaek and Toledo types, and is associated with abnormal androgen metabolism. PMID: 23824674
    7. Papss2 expression is reduced in articular cartilage following transforming growth factor-beta administration. PMID: 22394585
    8. PAPSS2 is the disease gene for an autosomal recessive brachyolmia. PMID: 22791835
    9. Unusual localisation signals of both PAPS synthase isoforms, are described. PMID: 22242175
    10. Thirty-seven novel SNPs in the PAPSS2 gene and in two intergenic regions on chromosomes 2q33.1 and 18p11.32 were associated with exercise participation. PMID: 19727025
    11. Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2. PMID: 11931653

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  • 相关疾病：
    Brachyolmia type 4 with mild epiphyseal and metaphyseal changes (BCYM4)
  • 蛋白家族：
    APS kinase family; Sulfate adenylyltransferase family
  • 组织特异性：
    Expressed in cartilage and adrenal gland.
  • 数据库链接：

    HGNC: 8604

    OMIM: 603005

    KEGG: hsa:9060

    STRING: 9606.ENSP00000406157

    UniGene: Hs.524491