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PARP3 Antibody

  • 货号：
    CSB-PA148428
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA148428(PARP3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA148428(PARP3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6F1
  • 基因名：
  • 别名：
    ADP ribosyltransferase (NAD+, poly (ADP ribose) antibody; ADP ribosyltransferase diphtheria toxin like 3 antibody; ADPRT-3 antibody; ADPRT3 antibody; ADPRTL2 antibody; ADPRTL3 antibody; ARTD3 antibody; hPARP 3 antibody; hPARP-3 antibody; hPARP3 antibody; IRT 1 antibody; IRT1 antibody; NAD(+) ADP ribosyltransferase 3 antibody; NAD(+) ADP-ribosyltransferase 3 antibody; NAD+ ADP ribosyltransferase 3 antibody; pADPRT 3 antibody; pADPRT-3 antibody; pADPRT3 antibody; PARP 3 antibody; PARP-3 antibody; PARP3 antibody; PARP3_HUMAN antibody; Poly (ADP ribose) polymerase family, member 3 antibody; Poly (ADP ribose) synthetase 3 antibody; Poly [ADP-ribose] polymerase 3 antibody; Poly[ADP ribose] synthetase 3 antibody; Poly[ADP-ribose] synthase 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human PARP3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRCC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin.
  • 基因功能参考文献：
    1. These data identify PARP3 as a molecular sensor of nicked nucleosomes. PMID: 27530147
    2. PARP3 controls of TGFbeta-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2/SNAI1 signaling. PMID: 27579892
    3. Data indicate that PARP3, a DNA damage-activated ADP-ribosyltransferase, can mono-ADP-ribosylate double-stranded DNA ends. PMID: 29054115
    4. In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B. PMID: 27716488
    5. we found that PARP3 interacted with FoxM1 to enhance its transcriptional activity and conferred glioblastoma cell radioresistance. Thus, our data suggest that PARP3 could be a therapeutic target to overcome radioresistance in glioblastoma PMID: 26040766
    6. Identification of ADP-ribosylation sites in PARP3 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed. PMID: 25800440
    7. MiR-630 reduced apoptosis by downregulating several apoptotic modulators, PARP3, DDIT4, and EP300. PMID: 25255219
    8. In some cancer cells, repression of PARP3 could be responsible for an increased telomerase activity. PMID: 24528514
    9. PARP3 likely facilitates the recruitment of Ku80 to double strand breaks to antagonize DNA end resection but facilitate Ku-mediated accurate classical non-homologous end-joining. PMID: 24598253
    10. PARP3 gene occupancy in the human neuroblastoma cell line SK-N-SH occurs preferentially with developmental genes regulating cell fate specification, tissue patterning, craniofacial development and neurogenesis. PMID: 21264220
    11. PARP3 is a critical player in the stabilization of the mitotic spindle and in telomere integrity by associating and regulating the mitotic components NuMA and tankyrase 1. PMID: 21270334
    12. PARP-3 has a role in chromosomal DNA double-strand break repair. PMID: 21211721
    13. the interaction between PARP-1 and PARP-3 is unrelated to DNA single-strand break repair PMID: 20064938
    14. PARP-3 is a nuclear protein involved in transcriptional silencing and in the cellular response to DNA damage PMID: 16924674

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  • 亚细胞定位：
    Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 组织特异性：
    Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
  • 数据库链接：

    HGNC: 273

    OMIM: 607726

    KEGG: hsa:10039

    STRING: 9606.ENSP00000381740

    UniGene: Hs.271742