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PARVA Antibody

  • 货号：
    CSB-PA017474GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NVD7
  • 基因名：
  • 别名：
    Actopaxin antibody; Alpha parvin antibody; Alpha-parvin antibody; Calponin like integrin linked kinase binding protein antibody; Calponin-like integrin-linked kinase-binding protein antibody; CH ILKBP antibody; CH-ILKBP antibody; FLJ10793 antibody; FLJ12254 antibody; Matrix remodelling associated 2 antibody; Matrix remodelling associated protein 2 antibody; Matrix-remodeling-associated protein 2 antibody; MXRA 2 antibody; MXRA2 antibody; PARV A antibody; Parva antibody; PARVA_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PARVA
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
  • 基因功能参考文献：
    1. edited form of miR-378a-3p preferentially binds to the 3'-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype PMID: 29386624
    2. Protein expression of alpha-Parvin increases with colorectal cancer progression. PMID: 26115385
    3. PARVA promotes metastasis by modulating ILK signalling pathway in lung adenocarcinoma PMID: 25738875
    4. alpha-pv-deficient HUVECs show reduced stable adherens junctions, decreased monolayer formation, and impaired motility, associated with reduced formation of integrin-mediated cell-extracellular matrix adhesion structures and an altered actin cytoskeleton. PMID: 25925587
    5. alpha-Parvin, a pseudopodial constituent, was found to promote migration of breast cancer cells and to be expressed exclusively by Invasive lobular carcinoma PMID: 24496929
    6. Actopaxin plays a role in hepatocellular carcinoma progression and metastasis, by way of regulation of cell invasiveness and motility, an epithelial-mesenchymal transition process, and chemosensitivity to cytotoxic drugs. PMID: 23504997
    7. beta2-adaptin is shown to bind to the focal adhesion protein actopaxin and localize to focal adhesions during cells spreading in an actopaxin dependent manner PMID: 23056266
    8. Actopaxin phosphorylation is required for matrix degradation and cell invasion via regulation of Rho GTPase signaling. PMID: 22955285
    9. results also identify the integrin-linked kinase (ILK) and alpha-parvin proteins as a new molecular partner and target, respectively, of the Lnk adaptor. PMID: 22441983
    10. the alpha-parvin CH2-paxillin LD1 complex has a role in focal adhesion assembly PMID: 18508764
    11. Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization. PMID: 11722847
    12. inhibition of the ILK-alpha-parvin complex is sufficient, although not necessary, for promotion of apoptosis PMID: 15284246
    13. Phosphorylation of actopaxin regulates cell spreading and migration. PMID: 15353548
    14. the association between actopaxin and TESK1, which is likely regulated by phosphorylation of actopaxin, regulates TESK1 activity and subsequent cellular spreading on fibronectin PMID: 15817463
    15. An unusual degree of binding degeneracy in the paxillin/alpha-parvin system that may facilitate the assembly of dynamic signaling complexes in the cell. PMID: 18940607

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton.
  • 蛋白家族：
    Parvin family
  • 组织特异性：
    Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
  • 数据库链接：

    HGNC: 14652

    OMIM: 608120

    KEGG: hsa:55742

    STRING: 9606.ENSP00000334008

    UniGene: Hs.432914