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PASD1 Antibody

  • 货号：
    CSB-PA816882LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PASD1 antibody at 4µg/ml + A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 88, 73 kDa
      Observed band size: 88 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PASD1 Polyclonal antibody
  • Uniprot No.：
    Q8IV76
  • 基因名：
    PASD1
  • 别名：
    Cancer/testis antigen 63 antibody; CT63 antibody; OX-TES-1 antibody; PAS domain containing 1 antibody; PAS domain-containing protein 1 antibody; PASD1 antibody; PASD1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Circadian clock protein PASD1 protein (301-600AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PASD1 Antibody (CSB-PA816882LA01HU)，的标记方式是Non-conjugated。对于PASD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA816882LB01HU PASD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA816882LC01HU PASD1 Antibody, FITC conjugated
    Biotin CSB-PA816882LD01HU PASD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed.
  • 基因功能参考文献：
    1. PASD1 serves as a critical nuclear positive regulator of STAT3-mediated gene expression and tumorigenesis. PMID: 26892021
    2. PASD1 is a circadian bHLH-PAS paralog repressor of CLOCK protein expression. PMID: 25936801
    3. PASD1-derived epitopes are both efficiently and selectively processed and presented by native human multiple myeloma cells as cancer vaccines. PMID: 20861911
  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.
  • 组织特异性：
    Testis-specific. Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific. Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widesp
  • 数据库链接：

    HGNC: 20686

    OMIM: 300993

    KEGG: hsa:139135

    STRING: 9606.ENSP00000359382

    UniGene: Hs.160594