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  4. Recombinant Human PAS domain-containing protein 1 (PASD1)

Recombinant Human PAS domain-containing protein 1 (PASD1)

  • 货号：
    CSB-YP816882HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP816882HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP816882HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP816882HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP816882HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PASD1
  • Uniprot No.：
  • 别名：
    Cancer/testis antigen 63; CT63; OX-TES-1; PAS domain containing 1; PAS domain-containing protein 1; PASD1; PASD1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-773
  • 氨基酸序列
    MKMRGEKRRD KVNPKSSQRK LNWIPSFPTY DYFNQVTLQL LDGFMITLST DGVIICVAEN ISSLLGHLPA EIVGKKLLSL LPDEEKDEVY QKIILKFPLL NSETHIEFCC HLKRGNVEHG DSSAYENVKF IVNVRDICNE FPVVFSGLFS SHLCADFAAC VPQEDRLYLV GNVCILRTQL LQQLYTSKAV SDEAVLTQDS DEEPFVGELS SSQGQRGHTS MKAVYVEPAA AAAAAAISDD QIDIAEVEQY GPQENVHMFV DSDSTYCSST VFLDTMPESP ALSLQDFRGE PEVNPLYRAD PVDLEFSVDQ VDSVDQEGPM DQQDPENPVA PLDQAGLMDP VDPEDSVDLG AAGASAQPLQ PSSPVAYDII SQELELMKKL KEQLEERTWL LHDAIQNQQN ALELMMDHLQ KQPNTLRHVV IPDLQSSEAV PKKQQKQHAG QVKRPLPHPK DVKCFCGLSL SNSLKNTGEL QEPCVAFNQQ QLVQQEQHLK EQQRQLREQL QQLREQRKVQ KQKKMQEKKK LQEQKMQEKK KLQEQRRQKK KKLQERKKWQ GQMLQKEPEE EQQKQQLQEQ PLKHNVIVGN ERVQICLQNP RDVSVPLCNH PVRFLQAQPI VPVQRAAEQQ PSGFYQDENC GQQEDESQSF YPEAYQGPPV NQLPLIDTSN SEAISSSSIP QFPITSDSTI STLETPQDYI RLWQELSDSL GPVVQVNTWS CDEQGTLHGQ PTYHQVQVSE VGVEGPPDPQ AFQGPAAYQP DQMRSAEQTR LMPAEQRDSN KPC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed.
  • 基因功能参考文献：
    1. PASD1 serves as a critical nuclear positive regulator of STAT3-mediated gene expression and tumorigenesis. PMID: 26892021
    2. PASD1 is a circadian bHLH-PAS paralog repressor of CLOCK protein expression. PMID: 25936801
    3. PASD1-derived epitopes are both efficiently and selectively processed and presented by native human multiple myeloma cells as cancer vaccines. PMID: 20861911
  • 亚细胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Nucleus.
  • 组织特异性：
    Testis-specific. Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific. Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widesp
  • 数据库链接：

    HGNC: 20686

    OMIM: 300993

    KEGG: hsa:139135

    STRING: 9606.ENSP00000359382

    UniGene: Hs.160594