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PAX1 Antibody

  • 货号：
    CSB-PA020238
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293T cells using Pax-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P15863
  • 基因名：
    PAX1
  • 别名：
    HUP48 antibody; OTTHUMP00000030407 antibody; Paired box 1 antibody; Paired box gene 1 antibody; Paired box protein Pax 1 antibody; Paired box protein Pax-1 antibody; Paired domain gene HuP48 antibody; PAX 1 antibody; Pax1 antibody; PAX1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Pax-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column.
  • 基因功能参考文献：
    1. The association between PAX1 and the susceptibility of AIS was successfully replicated in the Chinese population PMID: 29095406
    2. Hypermethylated ZNF582 and PAX1 genes in the oral scrapings collected from adjacent normal oral mucosal sites rather than cancer sites are associated with aggressive progression and poor prognosis of OSCC PMID: 29224816
    3. A novel PAX1 null homozygous mutation in autosomal recessive otofaciocervical syndrome associated with severe combined immunodeficiency has been described in a consanguineous family. PMID: 28657137
    4. PAX1 gene methylation was associated with the transition of CIN I to CIN II/III and CIN II/III to cervical cancer, so that it could be an auxiliary biomarker to estimate the risk of CIN progress. PMID: 28472814
    5. conclude that hypermethylated ZNF582 and PAX1 are effective biomarkers for the detection of oral dysplasia and oral cancer and for the prediction of oral cancer recurrence PMID: 27865370
    6. DNA methylation status of PAX1 showed a relatively good sensitivity and specificity for the detection of ESOPHAGEAL SQUAMOUS CELL CARCINOMA. PMID: 28241446
    7. Paired boxed gene 1 protein expression is a potential histopathology biomarker for the differential diagnosis of malignant and premalignant endometrial lesions. Paired boxed gene 1 is also a potential prognostic marker in cases of endometrial carcinoma. PMID: 27226215
    8. Hypermethylation of PAX1 gene may be highly associated with the development of cervical cancer. PMID: 26552048
    9. meta-analysis support the utility of PAX1 methylation as an auxiliary biomarker in cervical cancer screening PMID: 26234429
    10. Testing PAX1 DNA methylation using oral swabs is a promising method for oral cancer detection. Combined assessments regarding betel nut consumption and DNA methylation can improve OSCC screening PMID: 23907469
    11. PAX1 methylation hallmarks a potential diagnostic value for cervical cancer screening in Asians PMID: 26642709
    12. analysis of a PAX1 enhancer locus that is associated with susceptibility to idiopathic scoliosis in females PMID: 25784220
    13. PAX1 and SOX1 DNA methylation correlate with a cervical intraepithelial neoplasia diagnosis. PMID: 24799352
    14. PAX1 methylation is associated with cervical cancer. PMID: 24844223
    15. PAX1 methylation is associated with high-grade squamous intraepithelial lesions. PMID: 24568514
    16. Cervical adenocarcinoma cells carry aberrantly high methylation rates of PAX1, commonly methylated in squamous cell carcinomas. PMID: 24407576
    17. We identified PAX1 as a novel disease-causing gene for otofaciocervical syndrome and show that the pooling of DNA from affected individuals can reduce the number of putative disease-causing homozygous variants in consanguineous families. PMID: 23851939
    18. PAX1 hypermethylation is associated with cervical cancer. PMID: 20442585
    19. There was a significant reduction in PAX1 expression in fetuses with the Jarcho-Levin syndrome. PMID: 12833407
    20. No mutations were identified in the PAX1 and MEOX1 exons or flanking intronic sequences, excluding them as likely causative genes for diaphanospondylodysostosis PMID: 17764081

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  • 相关疾病：
    Otofaciocervical syndrome 2 (OTFCS2)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 8615

    OMIM: 167411

    KEGG: hsa:5075

    STRING: 9606.ENSP00000381499

    UniGene: Hs.122310