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  4. PAXIP1 Antibody

PAXIP1 Antibody

  • 货号：
    CSB-PA017496GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6ZW49
  • 基因名：
    PAXIP1
  • 别名：
    CAGF 28 antibody; CAGF 29 antibody; CAGF28 antibody; CAGF29 antibody; FLJ41049 antibody; PACIP 1 antibody; PACIP1 antibody; PAX interacting (with transcription activation domain) protein 1 antibody; PAX interacting protein 1 antibody; PAX transactivation activation domain-interacting protein antibody; PAX transcription activation domain interacting protein 1 like antibody; PAX-interacting protein 1 antibody; PAXI1_HUMAN antibody; PAXIP 1 antibody; PAXIP 1L antibody; paxip1 antibody; PAXIP1 protein antibody; PAXIP1L antibody; Protein encoded by CAG trinucleotide repeats antibody; PTIP antibody; TNRC 2 antibody; TNRC2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PAXIP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Proposed to recruit PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probably independent of MLL-containing histone methyltransferase (HMT) complexes. However, this function has been questioned. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes. Conflictingly, its function in transcriptional regulation during immunoglobulin class switching is reported to be independent of the MLL2/MLL3 complex.
  • 基因功能参考文献：
    1. PAXIP1 and 53BP1 protein levels followed gene expression results, i.e., are intrinsically correlated, and also reduced in more advanced breast cancer tumors. PMID: 28475402
    2. PAXIP1 is involved in sensitizing lung cancer cells to the WEE1 inhibitor AZD1775 in combination with platinum-based treatment. PMID: 27196765
    3. PTIP promotes double-strand break repair through a direct role in homologous recombination. PMID: 20088963
    4. PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation. PMID: 25631048
    5. uncovered a nuclease, Artemis, as a PTIP-binding protein PMID: 25512557
    6. PITX2 and PTIP co-occupy the promoter of the PITX2's transcriptional target. PMID: 24486544
    7. Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability. PMID: 22736030
    8. a new clue to identify the role of PTIP in DNA damage pathway PMID: 22064073
    9. PTIP controls expression of PPARgamma and C/EBPalpha, the two principal adipogenic transcription factors, and is therefore required for adipogenesis. PMID: 19583951
    10. PTIP (PAXIP1) is a strong inhibitor of the trans-activation activities of Pax2A and Pax2B on the glucagon gene promoter and p8 binding to PTIP prevents inhibition of this promoter. PMID: 11940591
    11. identified tandem BRCT (BRCA1 carboxyl-terminal) domains in PTIP and in BRCA1 as phosphoserine- or phosphothreonine-specific binding modules that recognize substrates phosphorylated by the kinases ATM and ATR in response to gamma-irradiation PMID: 14576432
    12. hPTIP (PAXIP1) shows increased association with 53BP1 in response to ionizing radiation but not in response to other DNA-damaging agents. PMID: 15456759
    13. Determination of a single ATM-phosphorylated residue in 53BP1--Ser25--that is required for binding of 53BP1 to hPTIP. PMID: 17690115
    14. PTIP depletion from mammalian cells by RNAi reduced PCNA ubiquitination in response to DNA damage, and also decreased the recruitment to chromatin of polymerase eta and the recombination protein Rad51 PMID: 18353733
    15. subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage. PMID: 19124460
    16. PTIP regulates 53BP1-dependent signaling pathway following DNA damage PMID: 19414588
    17. Without DNA damage agent treatment, endogenous PTIP associates with MLL3- and MLL4-containing histone H3 K4 methyltransferase complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, PA1 and JmjC domain-containing putative histone demethylase UTX. PMID: 17500065

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  • 亚细胞定位：
    Nucleus matrix. Chromosome.
  • 数据库链接：

    HGNC: 8624

    OMIM: 608254

    KEGG: hsa:22976

    STRING: 9606.ENSP00000384048

    UniGene: Hs.443881