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PBXIP1 Antibody

  • 货号：
    CSB-PA017509GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96AQ6
  • 基因名：
    PBXIP1
  • 别名：
    PBXIP1 antibody; HPIPPre-B-cell leukemia transcription factor-interacting protein 1 antibody; Hematopoietic PBX-interacting protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human PBXIP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
  • 基因功能参考文献：
    1. HPIP promotes gastric cancer cell proliferation through positive regulation of cap-dependent translation. PMID: 27748944
    2. Knockdown of HPIP suppressed TGF-beta1-induced EMT. PMID: 27178820
    3. our findings identified HPIP plays an important role in the progression and EMT of spinal glioblastoma, by which cell growth is improved. Thus, HPIP gene or protein could act as a useful target in the clinical practice. PMID: 26590606
    4. Copy number variations in PBXIP1 gene is associated with lung adenocarcinoma. PMID: 26497366
    5. HPIP may play critical role in oral carcinogenesis and is potential target for anticancer therapy, with particular emphasis on its involvement in differentiation and migration/metastasis. PMID: 25060351
    6. PBXIP1 is a novel protein overexpressed in astrocytoma and ependymoma, involved in tumor cell proliferation and migration PMID: 24470547
    7. These data highlight the important role of HPIP in liver cancer cell growth and suggest that HPIP may be a good target for liver cancer therapy. PMID: 24038948
    8. HPIP is a target of GATA1 and CTCF in erythroid cells and plays an important role in erythroid differentiation by modulating the PI3K/AKT pathway PMID: 22187427

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
  • 组织特异性：
    Expressed in early hematopoietic precursors.
  • 数据库链接：

    HGNC: 21199

    KEGG: hsa:57326

    STRING: 9606.ENSP00000357448

    UniGene: Hs.505806