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PCDH1 Antibody

  • 货号：
    CSB-PA2106ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PCDH1 antibody at 2.56μg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: Human breast cancer cell
      Lane 3: Jurkat whole cell lysate
      Lane 4: Hela whole cell lysate
      Lane 5: NIH/3T3 whole cell lysate
      Lane 6: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 115, 134 kDa
      Observed band size: 115 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA2106ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA2106ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PCDH1 Polyclonal antibody
  • Uniprot No.：
    Q08174
  • 基因名：
    PCDH1
  • 别名：
    Cadherin like 1 antibody; Cadherin like protein 1 antibody; Cadherin-like protein 1 antibody; FLJ53887 antibody; MGC45991 antibody; OTTHUMP00000160067 antibody; PC 42 antibody; PC42 antibody; PCDH 1 antibody; PCDH 42 antibody; PCDH1 antibody; PCDH1_HUMAN antibody; PCDH42 antibody; Protocadherin 1 antibody; Protocadherin 42 antibody; Protocadherin-1 antibody; Protocadherin-42 antibody; Protocadherin1 antibody; Protocadherin42 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Protocadherin-1 protein (60-220AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in cell-cell interaction processes and in cell adhesion.
  • 基因功能参考文献：
    1. Results show that PCDH1 is localized to the cell membrane of bronchial epithelial cells basolateral to the adherens junction. Its expression is not reduced nor delocalized in asthma even though PCDH1 contributes to homotypic adhesion, epithelial barrier formation and repair. PMID: 27701444
    2. PCDH1 is important for airway function as a physical barrier, and its dysfunction is involved in the pathogenesis of allergic airway inflammation. PMID: 26227965
    3. PCDH1 and SMAD3 act in a single pathway in asthma susceptibility that affects sensitivity of the airway epithelium to TGF-beta. PMID: 26209277
    4. Common variations in PCDH1 increase the risk of developing both transient early asthma and atopic dermatitis in early childhood PMID: 23988763
    5. genetic polymorphism is associated with subphenotypes of asthma in German children PMID: 23050600
    6. PCDH1 gene variant IVS3-116 associates with eczema in two independent birth cohorts in Netherlands. PMID: 21929597
    7. PCDH1 transcripts display remarkable variability in expression of conserved intracellular signaling domains; enhanced PCDH1 expression levels strongly correlate with differentiation of bronchial epithelial cells. PMID: 21982948
    8. PCDH1 is a novel gene for BHR in adults and children. Its identification as a BHR susceptibility gene may suggest that a structural defect in the integrity of the airway epithelium and contributes to the development of BHR. PMID: 19729670

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  • 亚细胞定位：
    Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
  • 组织特异性：
    Highly expressed in the brain and neuro-glial cells.
  • 数据库链接：

    HGNC: 8655

    OMIM: 603626

    KEGG: hsa:5097

    STRING: 9606.ENSP00000287008

    UniGene: Hs.79769