PCDH10 Antibody

1. PCDH10 hypermethylation were found in 54.2% (58/107) of DLBCL cases, but only 12.5% (1/8) in reactive lymph node/follicular hyperplasia. PMID: 29202805
2. This study provides insights into the tumorigenesis and progression of hepatocellular carcinoma (HCC), and puts forward the novel hypothesis that PCDH10 could be a new biomarker for HCC, or that combined with other molecular markers could increase the specificity and sensitivity of diagnostic tests for HCC. Restoration of PCDH10 could be a valuable therapeutic target for HCC. PMID: 28498423
3. we found that the malignant character of GISTs was initiated and amplified by PCDH10 in a process regulated by HOTAIR. In summary, our findings imply that PCDH10 and HOTAIR may be useful markers of disease progression and therapeutic targets. PMID: 27659532
4. we found that long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion PMID: 26871474
5. These findings suggest that Pcdh10 may influence subcellular actin cytoskeletal organization and axon-axon interactions in the course of familial amyloidotic polyneuropathy PMID: 27338109
6. PCDH10 methylation in serum is a potential prognostic biomarker for prostate cancer. PMID: 26881880
7. Study found that hypermethylation of CpG probes in the promoter regions of HOXA9 and PCDH10 was associated with mature B-cell neoplasms. PMID: 26679037
8. Data show that protocadherin 10 (PCDH10) over-expression could significantly induce cell apoptosis, and restrain proliferation, invasion and migration ability of BXPC-3 pancreatic cancer cells. PMID: 26927373
9. Our present findings suggested that the hypermethylated CpG site counts of PCDH10 DNA promoter for evaluating the prognosis of GC was reasonable by using the D-BGS PMID: 26406945
10. PCDH10 methylation is a potential biomarker that predicts a poor prognosis after curative resection of pathological stage I non-small-cell lung cancer. PMID: 26276761
11. PCDH10 antagonized MM cell proliferation via the downregulation of Wnt/beta-catenin/BCL-9 signaling, whereas PCDH10 repressed the expression of AKT to promote the expression of GSK3beta and then to restrain the activation of beta-catenin PMID: 26081897
12. These results suggest an important role of p53 in regulating tumor cell migration through activating PCDH10 expression. PMID: 25590240
13. Aberrant methylation of PCDH10 predicts worse biochemical recurrence-free survival in patients with prostate cancer after radical prostatectomy. PMID: 25086586
14. Gastric cancer patients with 5 or more methylated CpG sites of PCDH10 promoter had significantly poorer survival. PMID: 25260683
15. Findings establish a novel PCDH10-Wnt/beta-catenin-MALAT1 regulatory axis that contributes to EEC development. PMID: 25085246
16. These results indicate that promoter methylation status of PCDH10, SPARC, and UCHL1 may be used both as prognostic and predictive molecular marker for colorectal cancer patients PMID: 24309322
17. Loss of PCDH10 expression is associated with metastasis in colorectal cancer. PMID: 24740680
18. suppression of the expression of PCDH10 by RNA interference induces the growth arrest and apoptosis of glioblastoma cells in vitro PMID: 24406169
19. study suggests that PCDH10 methylation occurs early in lymphomagenesis. PCDH10 expression was down regulated via promoter hypermethylation in T- and B-cell lymphoma cell lines PMID: 23929756
20. The expression of PCDH10 was silenced in hepatocellular carcinoma via de novo DNA methylation. PMID: 22543497
21. There was a significant correlation between PCDH10 methylation in cfDNA and tumour tissue in patients with early CRC. PMID: 23839493
22. PCDH10 promoter methylation was detected in 59/117 (50.4%) of patients with bladder cancer, and none of 37 (0%) controls. Methylation was significantly associated with advanced stage, high grade, tumour recurrence and larger tumour size. PMID: 23321168
23. Downregulated PCDH10 levels correlated with malignant behaviour and poor overall survival in patients with bladder cancer. PMID: 23569128
24. PCDH10 methylation is closely associated with malignancy of bladder transitional cell carcinoma PMID: 23171734
25. PCDH10 is frequently downregulated by promoter methylation and may serve as a tumor suppressor gene in non-small cell lung cancer. PMID: 23321465
26. PCDH10 is an important tumor suppression gene with key roles of suppressing cell proliferation, clonogenicity, and inhibiting cell invasion in the development of colorectal cancer. PMID: 23180019
27. PCDH10 gene is a target for epigenetic silencing in multiple myeloma and provides a link between the dysregulation of angiogenesis and DNA methylation. PMID: 22245948
28. Data show that expression of PCDH10 is markedly reduced in gastric cancer cells and tissues, and suggest that it functions as a tumor suppressor gene in gastric cancer. PMID: 22206871
29. PCDH10 promoter hypermethylation was frequent in both B-cell (81.9%) and T-cell (80%) acute lymphoblastic leukemia (ALL). PMID: 21960365
30. genetic and epigenetic deregulation of PCDH10 occurs in a significant portion of medulloblastoma patients PMID: 21597995
31. The decreased PCDH10 expression in prostate cancer cells was associated with the aberrant methylation of PCDH10 promoter CpG islands. PMID: 21314642
32. Sp1/Sp3 and CBF/NF-Y transcription factors play a crucial role in the basal expression of the human PCDH10 gene. PMID: 21237250
33. epigenetic regulation of PCDH10 was associated with carcinogenesis. PMID: 20353276
34. Showed aberrant promoter hypermethylation of PCDH10 is assoc'd with downreg'n of gene expression in cervical cancer, and the promoter methylation in the PCDH10 gene occurs at an earliest identifiable stage of low-grade squamous intraepithelial lesion. PMID: 19681120
35. Ectopic expression of PCDH10 strongly suppressed tumor cell growth, migration, invasion and colony formation. PMID: 16247458
36. These results suggest that OL-pc remodels the motility and adhesion machinery at cell junctions by recruiting the Nap1-WAVE1 complex to these sites and, in turn, promotes the migration of cells. PMID: 18644894
37. PCDH10 is a gastric tumor suppressor; its methylation at early stages of gastric carcinogenesis is an independent prognostic factor. PMID: 19084528
38. The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation. PMID: 19262141
39. field methylation of the PCDH10 gene specifically in the invasion stage of cervical carcinogenesis, which might be used to develop a highly specific diagnostic test for cervical scrapings. PMID: 19709077

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HGNC: 13404

OMIM: 608286

KEGG: hsa:57575

STRING: 9606.ENSP00000264360

UniGene: Hs.192859