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PCDH11Y Antibody

  • 中文名称：
    PCDH11Y兔多克隆抗体
  • 货号：
    CSB-PA017527GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BZA8
  • 基因名：
    PCDH11Y
  • 别名：
    PCDH11Y antibody; PCDH11 antibody; PCDH22 antibody; PCDHY antibody; Protocadherin-11 Y-linked antibody; Protocadherin-11 antibody; Protocadherin on the Y chromosome antibody; PCDH-Y antibody; Protocadherin prostate cancer antibody; Protocadherin-PC antibody; Protocadherin-22 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human PCDH11Y
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potential calcium-dependent cell-adhesion protein.
  • 基因功能参考文献：
    1. In the present study, PCDH11Yb, but not PCDH11Ya or PCDH11Yc, was expressed in germ cells isolated from the semen of all 13 men with proven fertility. However, in several subjects from various infertility classes, there was complete absence or a significant reduction in the expression of PCDH11Yb. In conclusion, expression levels of PCDH11Yb in germ cells in the semen were correlated with the fertility status of men. PMID: 28241900
    2. PCDH11Y expression was detected in the fetal neocortex, ganglionic eminences, cerebellum, and inferior olive. In the adult brain, the cerebral cortex, hippocampal formation, and cerebellum and brain stem were immunoreactive. PMID: 22744706
    3. the PCDH11X/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens PMID: 23600975
    4. Our data...extended the lack of association of late-onset Alzheimer's disease to common PCDH11Y variants. PMID: 21276771
    5. The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes. PMID: 19859901
    6. A 4.8 kb cDNA was cloned from TPA-resistance LNCaP prostate cancer cells. It is an unusual protocadherin family gene with 2 large overlapping ORFs encoding homologous polypeptides, one with and one without a signal sequence. [protocadherin-PC] PMID: 12420223
    7. Findings do not support the role of PCDH11Y, or more generally of a frequent specific Y chromosome, in the susceptibility to these neuropsychiatric disorders. PMID: 16331680
    8. Our findings suggest a novel mechanism for the progression of CaP involving expression of PCDH-PC. This novel protocadherin induces Wnt signaling, promotes malignant behavior and hormone-resistance of CaP cells. PMID: 16637074
    9. This study provided the evidence for positive selection on Protocadherin Y gene in human lineage for schizophrenia. PMID: 18938061
    10. We consider that a stronger case can be mounted for the Protocadherin11X/Y gene pair located in the hominid specific Xq21.3/Yp11.2 region of homology that was generated by a duplication from the X PMID: 19125366
    11. a candidate for the evolution of hominid-specific characteristics including the sexual dimorphism of cerebral asymmetry, a putative correlate of language PMID: 16874762

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  • 相关疾病：
    A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.
  • 数据库链接：

    HGNC: 15813

    OMIM: 400022

    KEGG: hsa:83259

    UniGene: Hs.655673