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PCOLCE Antibody

  • 货号：
    CSB-PA614881LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA614881LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PCOLCE Polyclonal antibody
  • Uniprot No.：
    Q15113
  • 基因名：
    PCOLCE
  • 别名：
    PCOC1_HUMAN antibody; Pcolce antibody; PCOLE 1 antibody; PCOLE1 antibody; PCPE antibody; PCPE-1 antibody; PCPE1 antibody; Procollagen C endopeptidase enhancer antibody; Procollagen C-endopeptidase enhancer 1 antibody; Procollagen C-endopeptidase enhancer antibody; Procollagen C-proteinase enhancer 1 antibody; Procollagen COOH-terminal proteinase enhancer 1 antibody; procollagen, type 1, COOH-terminal proteinase enhancer antibody; Type 1 procollagen C-proteinase enhancer protein antibody; Type I procollagen COOH-terminal proteinase enhancer antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Procollagen C-endopeptidase enhancer 1 protein (169-449AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PCOLCE Antibody (CSB-PA614881LA01HU)，的标记方式是Non-conjugated。对于PCOLCE Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA614881LB01HU PCOLCE Antibody, HRP conjugated ELISA
    FITC CSB-PA614881LC01HU PCOLCE Antibody, FITC conjugated
    Biotin CSB-PA614881LD01HU PCOLCE Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
  • 基因功能参考文献：
    1. Serum PCPE-1 might be used as a noninvasive marker of liver fibrosis in chronic hepatitis B. PMID: 29683980
    2. Results suggest that PCPE-1 binding to syndecans and/or fibronectin may control collagen fibril assembly on the cell surface. PMID: 25286301
    3. The analysis of the PCPE-1 interaction network based on Gene Ontology terms suggests that, besides its role in collagen deposition, PCPE-1 might be involved in tumour growth, neurodegenerative diseases and angiogenesis. PMID: 24117177
    4. The results of this study suggested that nuclear entrapment of PCOLCE and its extracellular depletion represents a novel molecular mechanism in late-onset muscle fibrosis. PMID: 23815790
    5. Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation. PMID: 23550162
    6. data generated by our system, support our hypothesis that combined data on PCPE concentration and isoforms may be useful for the diagnosis and follow-up of bone diseases PMID: 21569766
    7. Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only. PMID: 21940633
    8. procollagen C-proteinase enhancer-1 (PCPE-1) binds to heparin/heparan sulfate and has a role in interaction with cells PMID: 20729553
    9. Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. PMID: 20207734
    10. Data show that only those containing both PCPE1 CUB1 and CUB2 were capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity. PMID: 19801683
    11. PCPE binds to sites on either side of the procollagen cleavage site, thereby facilitating the action of procollagen C-proteinases. PMID: 12105202
    12. PCPE1 and PCPE2 were found to be collagen-binding proteins, capable of binding at multiple sites on the triple helical portions of fibrillar collagens and also capable of competing for such binding with procollagen C-proteinases PMID: 12393877
    13. procollagen C-proteinase enhancer is an elongated multidomain glycoprotein as shown by small angle x-ray scattering PMID: 12486138
    14. the three-dimensional structure of the NTR domain of human PCOLCE1 is the first example of a structural domain with the canonical features of an NTR module PMID: 12670942
    15. chordinase activity of BMP1 is not enhanced by PCPE-1 PMID: 15817489
    16. tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
    17. PCPE-stimulating activity requires a calcium binding motif in the CUB1 domain that is highly conserved among CUB-containing proteins PMID: 17446170
    18. in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III. PMID: 17602227
    19. PCPE-1 interacts with beta2-microglobulin (beta2-m) and may help initiate beta2-m amyloid fibril formation in connective tissues PMID: 18164932
    20. Procollagen I mRNA expression was decreased by synovial fluid from patients with prosthesis loosening. PMID: 18350290
    21. the sPCPE1 glycopattern appears to be associated with the physiological and pathological states of bone PMID: 19361460

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 8738

    OMIM: 600270

    KEGG: hsa:5118

    STRING: 9606.ENSP00000223061

    UniGene: Hs.202097