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PDE1A Antibody

  • 货号：
    CSB-PA22739A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA22739A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDE1A Polyclonal antibody
  • Uniprot No.：
    P54750
  • 基因名：
  • 别名：
    3' 5' cyclic nucleotide phosphodiesterase antibody; 5''-cyclic nucleotide phosphodiesterase 1A antibody; 61 kDa Cam PDE antibody; 61 kDa Cam-PDE antibody; Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody; Calcium/Calmodulin stimulated cyclic nucleotide phosphodiesterase antibody; Calcium/calmodulin-dependent 3'' antibody; Calmodulin-dependent Phosphodiesterase antibody; Cam PDE 1A antibody; Cam-PDE 1A antibody; CAM-PDE-1A antibody; HCAM 1 antibody; hCam-1 antibody; HCAM1 antibody; HSPDE1A antibody; MGC26303 antibody; PDE 1A antibody; PDE1A antibody; PDE1A_HUMAN antibody; Phosphodiesterase 1A antibody; Phosphodiesterase 1A calmodulin dependent antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A protein (1-219AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDE1A Antibody (CSB-PA22739A0Rb)，的标记方式是Non-conjugated。对于PDE1A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA22739B0Rb PDE1A Antibody, HRP conjugated ELISA
    FITC CSB-PA22739C0Rb PDE1A Antibody, FITC conjugated
    Biotin CSB-PA22739D0Rb PDE1A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
  • 基因功能参考文献：
    1. evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts. PMID: 29262781
    2. Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness. PMID: 26464516
    3. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis PMID: 22012077
    4. PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1. PMID: 20807569
    5. PDE1A is permanently activated in human spermatozoa PMID: 12135876
    6. Ca2+-calmodulin-dependent phosphodiesterase 1A is activated by sustained entry of Ca2+ PMID: 15272012
    7. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis. PMID: 16514069
    8. Variants in PDE1A are not associated with citalopram response in patient with depression. PMID: 18043711
    9. PDE1A is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142

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  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
  • 组织特异性：
    Several tissues, including brain, kidney, testes and heart.
  • 数据库链接：

    HGNC: 8774

    OMIM: 171890

    KEGG: hsa:5136

    STRING: 9606.ENSP00000331574

    UniGene: Hs.191046