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PDE1B Antibody

  • 货号：
    CSB-PA27759A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, A549 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate
      All lanes: PDE1B antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 62, 60 kDa
      Observed band size: 62 kDa
    • Immunofluorescence staining of MCF-7 with CSB-PA27759A0Rb at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDE1B Polyclonal antibody
  • Uniprot No.：
    Q01064
  • 基因名：
  • 别名：
    5''-cyclic nucleotide phosphodiesterase 1B antibody; 63 kDa Cam PDE antibody; 63 kDa Cam-PDE antibody; Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B antibody; Calcium/calmodulin stimulated cyclic nucleotide phosphodiesterase antibody; Calcium/calmodulin-dependent 3'' antibody; Calmodulin stimulated phosphodiesterase PDE1B1 antibody; Cam PDE 1B antibody; Cam PDE1B antibody; Cam-PDE 1B antibody; PDE 1B antibody; PDE1B antibody; PDE1B_HUMAN antibody; PDE1B1 antibody; PDES 1B antibody; PDES1B antibody; Phosphodiesterase 1B antibody; Phosphodiesterase 1B calmodulin dependent antibody; Presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B protein (1-277AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDE1B Antibody (CSB-PA27759A0Rb)，的标记方式是Non-conjugated。对于PDE1B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA27759B0Rb PDE1B Antibody, HRP conjugated ELISA
    FITC CSB-PA27759C0Rb PDE1B Antibody, FITC conjugated
    Biotin CSB-PA27759D0Rb PDE1B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
  • 基因功能参考文献：
    1. The c.1618G>A, p.Gly540Ser substitution in CNGA3 was identified as the causative mutation for a novel form of ACHM in Awassi sheep. Gene augmentation therapy restored vision in the affected sheep. This novel mutation provides a large-animal model that is valid for most human CNGA3 ACHM patients; the majority of them carry missense rather than premature-termination mutations. PMID: 28282490
    2. Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation. PMID: 15625104
    3. PDE1B2 regulates a subset of phenotypic changes that occur upon phorbol-12-myristate-13-acetate-induced differentiation and likely also plays a role in differentiated macrophages by regulating agonist-stimulated cGMP levels PMID: 16407168
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
  • 数据库链接：

    HGNC: 8775

    OMIM: 171891

    KEGG: hsa:5153

    STRING: 9606.ENSP00000243052

    UniGene: Hs.530871