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PDE4B Antibody

  • 货号：
    CSB-PA21029A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA21029A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA21029A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDE4B Polyclonal antibody
  • Uniprot No.：
    Q07343
  • 基因名：
  • 别名：
    5''-cyclic phosphodiesterase 4B antibody; cAMP-specific 3'' antibody; cAMP-specific 3',5'-cyclic phosphodiesterase 4B antibody; cAMP-specific phosphodiesterase-4 B isoform antibody; DKFZp686F2182 antibody; DPDE4 antibody; dunce-like phosphodiesterase E4 antibody; MGC126529 antibody; OTTHUMP00000010652 antibody; OTTHUMP00000010653 antibody; OTTHUMP00000010654 antibody; OTTHUMP00000010656 antibody; OTTHUMP00000232365 antibody; PDE 4B antibody; PDE IVB antibody; PDE32 antibody; Pde4b antibody; PDE4B_HUMAN antibody; PDE4B5 antibody; PDEIVB antibody; Phosphodiesterase 4B antibody; Phosphodiesterase 4B cAMP specific antibody; Phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human cAMP-specific 3',5'-cyclic phosphodiesterase 4B protein (27-215AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDE4B Antibody (CSB-PA21029A0Rb)，的标记方式是Non-conjugated。对于PDE4B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA21029B0Rb PDE4B Antibody, HRP conjugated ELISA
    FITC CSB-PA21029C0Rb PDE4B Antibody, FITC conjugated
    Biotin CSB-PA21029D0Rb PDE4B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
  • 基因功能参考文献：
    1. Data suggest that maternal glycemic response during pregnancy is associated with lower DNA methylation of 4 CpG sites within PDE4B gene in placenta (collected after term birth); 3 additional CpG sites are differentially methylated relative to maternal glucose response within TNFRSF1B, LDLR, and BLM genes. (TNFRSF1B = TNF receptor superfamily member-1B; LDLR = low density lipoprotein receptor; BLM = Bloom syndrome protein) PMID: 29752424
    2. Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition. PMID: 29100790
    3. HTT forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4) to regulate PDE4 activity. PMID: 28263187
    4. Low PDE4B expression is associated with sepsis. PMID: 28356347
    5. PDE4B gene may be involved in the testicular abnormalities of men with DS and cryptorchidism. PMID: 25546171
    6. This meta-analysis suggests that PDE4B SNPs are genetically associated with susceptibility to schizophrenia. PMID: 26756575
    7. Our results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils PMID: 26011935
    8. Our results support previously reported association of PDE4B variations with schizophrenia in other populations. PMID: 25926551
    9. analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 PMID: 25831493
    10. ototopical post-inoculation administration of a PDE4 inhibitor suppresses inflammation in this animal model, thus demonstrating the therapeutic potential of targeting PDE4 PMID: 23575688
    11. PDE4B was found to be highly expressed in CD4+ lymphoid cancer cells, which suggests that it may represent a physiological role unique to the CD8+ and lymphoid cancer cells and thus might represent a target for treatment of certain lymphoid diseases PMID: 23451206
    12. Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and PDE4B proteins but fully interact with fasciculation/elongation zeta (FEZ)1 and glycogen synthase kinase 3 GSK3beta. PMID: 22832604
    13. a study of Northwestern Han Chinese found that rs472952 is significantly associated with schizophrenia (SCZ) and rs7537440 is associated with SCZ in females; results provide further evidence that PDE4B may play important roles in the etiology of SCZ PMID: 22160351
    14. PDE4B was downregulated and the protein kinase A pathway was activated in castration-resistant LNCaP prostate cancer cells. PDE4B expression was reduced in advanced prostate cancer and PDE4B knockdown promoted castration-resistant growth of LNCaP cells. PMID: 22529021
    15. The reported anti-inflammatory activity of bresol might be attributed to its abilities to inhibit PDE4B and thus elevate cAMP levels in human monocytes. PMID: 21854221
    16. Overexpression of the PDE4B in diffuse large B-cell lymphoma (DLBCL) impinge on the same genes/pathways that are abnormally active in GC-resistant tumors. PMID: 21742807
    17. found a significant association between PDE4B and PD in the haplotype analysis. Sex-specific analyses demonstrated that PDE4B was associated with PD in females. results suggest PDE4B may play a role in the pathophysiology of PD in the Japanese population. PMID: 21184794
    18. Molecular dynamic simulations (with data from crystal structure of catalytic domain of PDE4B with cAMP bound) are used to investigate the catalytic mechanism of PDE4B in the hydrolysis of cAMP. PMID: 21595828
    19. these data allow the assignment of different PDE4 subtypes to distinct functions of human lung fibroblasts and highlight the predominant role of PDE4B in controlling pathophysiological processes of human lung fibroblasts. PMID: 21520048
    20. results do not support a genetic association between tardive dyskinesia and PDE4B PMID: 20436352
    21. TCR-dependent signaling activates PDE4B2 and enhances interleukin-2 production in T cells. PMID: 14585965
    22. clinically relevant PDE4 and PI3K/AKT inhibitors might be useful in the treatment of Diffuse large B-cell lymphoma and additional B-lymphoid malignancies with increased PDE4B expression PMID: 15331441
    23. a mechanistic model whereby DISC1 sequesters phosphodiesterase 4B in resting cells and releases it in an activated state in response to elevated cAMP PMID: 16293762
    24. Reverse-transcription polymerase chain reaction confirmed increased expression of GADD45A, BTG2, PDE4B, and CEBPD and downregulation of TOB1 in skeletal muscle intradialysis. PMID: 16997058
    25. Compartmentalized PDE4B acts as a sink to drain cAMP from discrete locations, resulting in multiple domains with different cAMP concentrations. PMID: 17088426
    26. PDE4B haplotype alters the genetic risk of schizophrenia in the Scottish population complements the known participation of this gene in biological processes associated with mental illness PMID: 17417055
    27. A super-short, brain specific isoform of human PDE4B, PDE4B5, was identified. It has cAMP hydrolyzing activity and is inhibited by PDE4 inhibitors. PDE4B5 bind to DISC1. The 16 N-terminal residues are identical to the corresponding residues of PDE4D6. PMID: 17519386
    28. Altered DISC1-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression.(Review) PMID: 17823207
    29. Our result suggests that variations at the PDE4B locus may play a significant role in the etiology of SZ in the Japanese population. PMID: 18329668
    30. the present observations suggest that dysregulation of intracellular signaling mediated by PDE4B is a significant factor in the cause and expression, respectively, of schizophrenia. PMID: 18394866
    31. the PDE4B gene itself does not link to major depressive disorder (MDD) but the elevated mRNA levels of PDE4B might be implicated in the pathophysiology of MDD. PMID: 18785206
    32. NDE1, NDEL1 and LIS1, together with their binding partner dynein, associate with DISC1, PDE4B and PDE4D within the cell, and provide evidence that this complex is present at the centrosome. PMID: 18983980
    33. There was no strong evidence for association with PDE4B in schizophrenia. PMID: 19632097
    34. phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes, and that its up-regulation at the protein level is controlled by complex mechanisms PMID: 19728060
    35. Behavioral phenotypes of Disc1 missense mutations in mice and consequences for PDE4B PMID: 17481393

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  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
  • 组织特异性：
    Expressed in brain, heart, lung and skeletal muscle.
  • 数据库链接：

    HGNC: 8781

    OMIM: 600127

    KEGG: hsa:5142

    STRING: 9606.ENSP00000332116

    UniGene: Hs.198072