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PDE8B Antibody

  • 货号：
    CSB-PA529743LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA529743LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDE8B Polyclonal antibody
  • Uniprot No.：
    O95263
  • 基因名：
    PDE8B
  • 别名：
    3' 5' cyclic nucleotide phosphodiesterase 8B antibody; 3'5' cyclic nucleotide phosphodiesterase 8B antibody; Cell proliferation-inducing gene 22 protein antibody; FLJ11212 antibody; High affinity cAMP specific and IBMX insensitive 3' 5' cyclic phosphodiesterase 8B antibody; High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8B antibody; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B antibody; HSPDE 8B antibody; HsPDE8B antibody; PDE 8B antibody; PDE8B antibody; PDE8B_HUMAN antibody; Phosphodiesterase 8B antibody; Phosphodiesterase8B antibody; PIG22 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8Bprotein (18-110AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDE8B Antibody (CSB-PA529743LA01HU)，的标记方式是Non-conjugated。对于PDE8B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA529743LB01HU PDE8B Antibody, HRP conjugated ELISA
    FITC CSB-PA529743LC01HU PDE8B Antibody, FITC conjugated
    Biotin CSB-PA529743LD01HU PDE8B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.
  • 基因功能参考文献：
    1. Single-nucleotide polymorphism in PDE8B gene is associated with Hashimoto's thyroiditis. PMID: 28382505
    2. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation PMID: 28727628
    3. a heterozygous nonsense mutation in the first exon of cyclic nucleotide phosphodiesterase 8B gene, which is predicted to disrupt all important functional domains of the cyclic nucleotide phosphodiesterase 8B protein, in two members of family with autosomal-dominant striatal degeneration PMID: 26769607
    4. Genetic variation of the PDE8B gene may be involved in the etiology of subclinical hypothyroidism in pregnant women. PMID: 25822812
    5. A prevalence of the minor allele of PDE8B gene polymorphism associated with elevated serum levels of TSH was demonstrated in patients affected by sporadic nonautoimmune subclinical hypothyroidism. PMID: 24497218
    6. rs4704397 is associated with thyroid function, risk of MI, and body height. PMID: 23941514
    7. rs4704397 in phosphodiesterase 8B is associated with thyrotropin and thyroid hormone concentrations PMID: 23272636
    8. There is an association between homozygous A/A as well as homozygous G/G carriers of SNP rs 4704397 in PDE8B and recurrent miscarriage. PMID: 23237535
    9. PDE8B gene polymorphisms may be correlated with hyperthyroxinemia in the Chinese Han population. PMID: 22781450
    10. PDE8B is another PDE gene in which variations may contribute to predisposition of adrenocortical tumours. PMID: 22335482
    11. In obese children, PDE8B is associated with TSH; the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model. PMID: 22084153
    12. Common genetic variation in PDE8B is associated with reciprocal changes in thyroid hormone levels. PMID: 21317282
    13. Our analysis revealed separate segregation of an inactivating PDE8B allele from the high-TSH-allele and showed low TSH levels in persons who carry an inactivating PDE8B allele. These data suggest that PDE8B may be involved in regulation of TSH levels. PMID: 20373981
    14. phosphodiesterase 8B has a role in autosomal-dominant striatal degeneration PMID: 20085714
    15. selective usage of exons produces three different PDE8B variants that exhibit a tissue-specific expression pattern PMID: 12372422
    16. Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A. PMID: 12681444
    17. In Alzheimer's disease brains we found that PDE8B was the only PDE isozyme showing a significant increase, in cortical areas and parts of the hippocampal formation, at Braak stages III-VI PMID: 12895443
    18. PDE8B is another PDE gene linked to isolated micronodular adrenocortical disease; it is a candidate causative gene for other adrenocortical lesions linked to the cAMP signaling pathway and possibly for tumors in other tissues. PMID: 18431404
    19. results suggest a primary effect of PDE8B variants on cAMP levels in the thyroid. This would affect production of T4 and T3 and feedback to alter TSH release by the pituitary. PMID: 18514160
    20. Genetic variation in thyroid stimulating hormone levels in pregnancy associated with the PDE8B rs4704397 genotype has implications for the number of women treated for subclinical hypothyroidism under current guidelines PMID: 19820008

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  • 相关疾病：
    Striatal degeneration, autosomal dominant 1 (ADSD1); Primary pigmented nodular adrenocortical disease 3 (PPNAD3)
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE8 subfamily
  • 组织特异性：
    Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain
  • 数据库链接：

    HGNC: 8794

    OMIM: 603390

    KEGG: hsa:8622

    STRING: 9606.ENSP00000264917

    UniGene: Hs.584830