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PDE9A Antibody

  • 货号：
    CSB-PA527985GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDE9A Polyclonal antibody
  • Uniprot No.：
    O76083
  • 基因名：
    PDE9A
  • 别名：
    5''-cyclic phosphodiesterase 9A antibody; cGMP specific 3' 5' cyclic phosphodiesterase type 9 antibody; FLJ90181 antibody; High affinity cGMP-specific 3'' antibody; High-affinity cGMP-specific 3'5'-cyclic phosphodiesterase 9A antibody; HSPDE9A2 antibody; OTTHUMP00000109399 antibody; PDE 9A antibody; Pde9a antibody; PDE9A_HUMAN antibody; Phosphodiesterase 9A antibody; phosphodiesterase PDE9A21 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human PDE9A protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory.
  • 基因功能参考文献：
    1. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target. PMID: 25799991
    2. it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer PMID: 22960860
    3. In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory. PMID: 22328573
    4. PDE9 is widely distributed in the urothelial epithelium of the human lower urinary tract and its potential roles may be different from those of PDE5. PMID: 21736695
    5. Data show that PDE9A inhibitor, BAY-73-6691, significantly reduced basal and sickle cell (SCA) neutrophil adhesion; this was accompanied by decreased SCA neutrophil surface expressions of the L-selectin and CD11b adhesion molecules. PMID: 21336703
    6. Identification and distribution of different variants produced by differential splicing of phosphodiesterase 9A mRNA. PMID: 12565835
    7. X ray crystallography with IBMX inhibitor binding PMID: 15210993
    8. The data suggests the utilization of two different start codons to produce a variety of different PDE9A proteins, allowing specific subcellular location of PDE9A splice variants. PMID: 17090334
    9. PDE9A, is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142

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  • 亚细胞定位：
    [Isoform PDE9A1]: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum. Cell membrane, sarcolemma.; [Isoform PDE9A2]: Cell projection, ruffle membrane. Cytoplasm, perinuclear region.; [Isoform PDE9A3]: Cytoplasm. Endoplasmic reticulum.; [Isoform PDE9A17]: Cytoplasm. Endoplasmic reticulum.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE9 subfamily
  • 组织特异性：
    Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isofo
  • 数据库链接：

    HGNC: 8795

    OMIM: 602973

    KEGG: hsa:5152

    STRING: 9606.ENSP00000291539

    UniGene: Hs.473927