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PDGFC Antibody

  • 货号：
    CSB-PA146607
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA146607(PDGFC Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA146607(PDGFC Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NRA1
  • 基因名：
  • 别名：
    Fallotein antibody; hSCDGF antibody; PDGF-C antibody; PDGFC antibody; PDGFC latent form antibody; PDGFC receptor-binding form antibody; PDGFC_HUMAN antibody; Platelet derived growth factor C antibody; Platelet-derived growth factor C; receptor-binding form antibody; SCDGF antibody; Secretory growth factor like protein antibody; Secretory growth factor like protein fallotein antibody; Spinal cord derived growth factor antibody; Spinal cord-derived growth factor antibody; VEGF E antibody; VEGF-E antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human PDGFC
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
  • 基因功能参考文献：
    1. There are four platelet-derived growth factor (PDGF) genes (PDGFA, PDGFB, PDGFC and PDGFD) that reside on chromosomes 7, 22, 4 and 11. PMID: 28267575
    2. We conclude that PDGF-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset PMID: 26687981
    3. High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes. PMID: 27033449
    4. PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR). PMID: 25383675
    5. Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells. PMID: 24612214
    6. The results indicate that PDGF-C upregulation and calpain-3 downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins PMID: 24126726
    7. Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation. PMID: 24421315
    8. Data indicate uPA (plau) and PAI1 (Serpine1) were up-regulated in human PDGF-C Tg mice, suggesting that uPA could be compensating for the loss of tissue-type plasminogen activator (tPA) activity in PDGF-C Tg; tpa KO mice. PMID: 24269585
    9. High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma. PMID: 23929039
    10. PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review] PMID: 23714575
    11. Results indicate that the alpha-SMA inducing effect of M2 macrophages is in part mediated by secretion of PGDF-CC. PMID: 23182716
    12. Single nucleotide polymorphisms in the PDGF-C gene are linked to the development of oral clefts. PMID: 23029525
    13. Platelet-derived growth factor-C (PDGF-C) activation by serine proteases. PMID: 22035541
    14. Melanoma cell-derived platelet-derived growth factor (PDGF)-AA and PDGF-CC were identified as major mediators that signal through PDGFR-alpha and thus induce HAS2-mediated HA synthesis in fibroblasts PMID: 21993555
    15. Data suggest that the variant rs1425486 genotype could differentially affect targeting by miR-425 in ovarian cancer cells leading to higher PDGFC expression. PMID: 21118967
    16. PDGFC mRNA expression were down-regulated in biopsies containing infiltrated lymphocytes or thyroiditis. PMID: 19968886
    17. Upregulation of PDGFC expression may contribute to the clonal expansion of fibroid-derived smooth muscle cells in the development of uterine fibroids. PMID: 19553600
    18. Data suggest that five novel genes, LUM, PDE3B, PDGF-C, NRG1 and PKD2, have great potential for predicting the efficacy of cisplatin-based chemotherapy against OSCC. PMID: 19569180
    19. Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. PMID: 12032822
    20. determination of PDGFC expression levels in medulloblastoma tumor cell lines PMID: 12176024
    21. PDGF-C has a higher structural homology to the vascular endothelial growth factor than to PDGF-B PMID: 12598536
    22. PDGF-C is constitutively expressed in the human kidney and is upregulated in podocytes and interstitial cells after injury/activation of these cells. PMID: 12707385
    23. In adult human tissues, PDGF-C was largely in smooth muscle. It binds & activate alpha PDGFR, & activates beta PDGFR when it is co-expressed with alpha PDGFR through heterodimer formation. PDGF C is likely to play a role in platelet biology. PMID: 15061151
    24. Plays a role in tissue remodeling. PMID: 15389578
    25. PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis PMID: 15728360
    26. determine the molecular mechanism of tPA-mediated activation of PDGF-C dimer PMID: 15911618
    27. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium. PMID: 17482170
    28. PDGF-C and PDGF-D, like PDGF-A and PDGF-B, play important roles in atherosclerosis by stimulating MMP activity and influencing monocyte migration PMID: 18573494
    29. A novel splice variant of human PDGF-C (PDGF-Cb), which encodes an N-terminally truncated protein, lacking the signal peptide and CUB domain, is reported. PMID: 18588873
    30. The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with cleft lip with or without cleft palate (CL/P) PMID: 19092777
    31. some tumors may overcome inhibition of VEGF-mediated angiogenesis through upregulation of PDGF-C PMID: 19111878
    32. PDGFC was identified as target of EWS/ETS transcriptionalderegulation specific to EWS/FLI-1 chimeras in the Ewing Family Tumors suggesting that it may be a significant mediator of EWS/FLI driven oncogenesis. PMID: 11313995

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  • 亚细胞定位：
    Cytoplasm, cytosol. Secreted. Nucleus. Cytoplasmic granule. Cell membrane.
  • 蛋白家族：
    PDGF/VEGF growth factor family
  • 组织特异性：
    Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutive
  • 数据库链接：

    HGNC: 8801

    OMIM: 608452

    KEGG: hsa:56034

    STRING: 9606.ENSP00000422464

    UniGene: Hs.570855