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PDLIM5 Antibody

  • 货号：
    CSB-PA006666
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using PDLIM5 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q96HC4
  • 基因名：
    PDLIM5
  • 别名：
    ENH antibody; ENH1 antibody; Enigma homolog antibody; Enigma like LIM domain protein antibody; Enigma like PDZ and LIM domains protein antibody; Enigma-like PDZ and LIM domains protein antibody; L 9 antibody; L9 antibody; LIM antibody; PDLI5_HUMAN antibody; PDLIM5 antibody; PDZ and LIM domain 5 antibody; PDZ and LIM domain protein 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from Human PDLIM5 around the non-phosphorylation site of Y251.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.
  • 基因功能参考文献：
    1. this study shows functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kidneyAE1 and actin cytoskeleton-associated proteins in polarized cells PMID: 28045035
    2. PDLIM5 promotes papillary thyroid carcinoma via activation of the Ras-ERK pathway. PMID: 29574154
    3. PDLIM5 was strongly up-regulated during cardiomyogenesis and novel stage-specific isoforms were detected for PDLIM5 PMID: 28139119
    4. Findings provide evidence of shared genetic variants in PDLIM5 gene influencing alcohol dependence, type 2 diabetes, and hypertension. PMID: 27693979
    5. The study provides evidence of several genetic variants within the PDLIM5 gene and interactions between PDLIM5 and steroid use influencing cancer. PMID: 27350677
    6. It can be deduced that the nonsynonymous rs7690296 polymorphism of PDLIM5 could play an important role in the pathophysiology of both bipolar disorder and schizophrenia. PMID: 24064681
    7. PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. PMID: 22741436
    8. The significant difference in expression of PDLIM5 mRNA in the peripheral blood leukocytes of treatment-naive bipolar (BPD) patients versus that of healthy control subjects suggests that it may be a good biological marker for BPD. PMID: 23031404
    9. LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner. PMID: 21266195
    10. Altered expression of LIM was found in brains and lymphoblastoid cells from patients with bipolar disorder. PMID: 14743183
    11. It is confirmed a decreased expression of LIM in the lymphoblastoid cell lines from patients with bipolar I disorder and schizophrenia. PMID: 15362566
    12. Western blot studies of muscle tissues revealed that ENH4 is present only in skeletal muscle and there is a specific distribution of ENH members between skeletal and cardiac muscles, which is different in human and mouse. PMID: 15555569
    13. Genetic association study revealed the association of single nucleotide polymorphism (SNP)1 (rs10008257) with bipolar disorder. PMID: 16044170
    14. ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors PMID: 16549780
    15. Our investigation indicates that the lower expression levels of LIM mRNA in the peripheral leukocytes are associated with the depressive state and that its recovery after treatment may be an adaptive change induced by the antidepressant. PMID: 16595163
    16. We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients. PMID: 17287082
    17. our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia PMID: 18021463
    18. PDLIM5 gene is associated with recurrent major depressive disorder. PMID: 18197271
    19. tested for an association between three single nucleotide polymorphisms at the PDLIM5 gene and lithium prophylaxis in a Sardinian sample comprised of 155 bipolar patients treated with lithium PMID: 18456508
    20. PDLIM5 may have a minor effect on susceptibility to bipolar disorder in Caucasians. PMID: 18496208
    21. The aim of this study was to investigate the association between PDLIM5 single nucleotide polymorphisms and bipolar disorder in a case-control sample. PMID: 18496210
    22. Our results suggest that PDLIM5 might play a role in susceptibility to bipolar disorder among the Chinese Han population. PMID: 19448850

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic density. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cytoplasm, cytosol.
  • 组织特异性：
    Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
  • 数据库链接：

    HGNC: 17468

    OMIM: 605904

    KEGG: hsa:10611

    STRING: 9606.ENSP00000321746

    UniGene: Hs.480311