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PDP1 Antibody

  • 货号：
    CSB-PA878946LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate
      All lanes: PDP1 antibody at 3.6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 62, 64 kDa
      Observed band size: 62 kDa
    • IHC image of CSB-PA878946LA01HU diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDP1 Polyclonal antibody
  • Uniprot No.：
    Q9P0J1
  • 基因名：
    PDP1
  • 别名：
    [Pyruvate dehydrogenase [acetyl transferring]] phosphatase 1; mitochondrial antibody; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1 antibody; FLJ32517 antibody; Gm1024 antibody; MGC119646 antibody; mitochondrial antibody; PDH antibody; PDP 1 antibody; PDP antibody; Pdp1 antibody; PDP1_HUMAN antibody; PDPC 1 antibody; PDPC antibody; PPM2C antibody; Protein phosphatase 2C antibody; protein phosphatase 2C; magnesium dependent; catalytic subunit antibody; Pyruvate dehydrogenase (Lipoamide) phosphatase phosphatase antibody; Pyruvate dehydrogenase phosphatase catalytic subunit 1 antibody; Pyruvate dehydrogenase phosphatase; catalytic subunit 1 antibody; RP23 203A12.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial protein (1-154AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PDP1 Antibody (CSB-PA878946LA01HU)，的标记方式是Non-conjugated。对于PDP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA878946LB01HU PDP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA878946LC01HU PDP1 Antibody, FITC conjugated
    Biotin CSB-PA878946LD01HU PDP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
  • 基因功能参考文献：
    1. High PDH expression is associated with glucose intolerance. PMID: 28148899
    2. YB-1 phosphorylation at Ser-102 is an important prerequisite for CCL5 promoter activation during macrophage differentiation PMID: 24962578
    3. the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3 PMID: 24486017
    4. Although 7 days of bed rest induced whole body glucose intolerance, exercise-induced PDH regulation in skeletal muscle was not changed, suggesting that exercise-induced PDH regulation in skeletal muscle is maintained in glucose-intolerant individuals. PMID: 21680880
    5. catalytic subunit of PDP1 crystals belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c = 216.1 A. PMID: 20208177
    6. pyruvate dehydrogenase phosphatase PDP1 is down-regulated in circulating lymphocytes of obese subjects because it is poorly sensitive to magnesium/calcium; this defect is attenuated when plasma insulin is greatly enhanced PMID: 15897476
    7. Lower accumulation of free ADP and AMP after the FAT-adapt trial may be responsible for the decreased glycogenolysis and PDH activation during sprinting. PMID: 16188909
    8. Functional characterization of the bovine counterpart. PMID: 8396421
    9. Functional characterization of the rat counterpart. PMID: 9651365
    10. In cultured skin fibroblasts from three patients with congenital lactic acidemia due to a defect in activation of the pyruvate dehydrogenase complex, the PDP-activity was significantly reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts. PMID: 1327585
    11. In postmortem tissue samples, from male child with metabolic acidosis, PDK normally reduced PDH-activity in ATP-presence. Addition of Ca++ and Mg++ did not restored PDH-activity. The defect was attributed to a markedly reduced PDP-activity. PMID: 172850

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  • 相关疾病：
    Pyruvate dehydrogenase phosphatase deficiency (PDP deficiency)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    PP2C family
  • 数据库链接：

    HGNC: 9279

    OMIM: 605993

    KEGG: hsa:54704

    STRING: 9606.ENSP00000379503

    UniGene: Hs.22265