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PDXK Antibody

  • 货号：
    CSB-PA017748ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: PDXK antibody at 5.63µg/ml
      Lane 1: Mouse liver tissue
      Lane 2: Hela whole cell lysate
      Lane 3: Mouse kidney tissue
      Lane 4: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 36, 32, 27 kDa
      Observed band size: 36 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA017748ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017748ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PDXK Polyclonal antibody
  • Uniprot No.：
    O00764
  • 基因名：
    PDXK
  • 别名：
    pdxK antibody; PDXK_HUMAN antibody; PKH antibody; PNK antibody; Pyridoxal kinase antibody; Pyridoxamine kinase antibody; Pyridoxine kinase antibody; Pyridoxine kinase; antibody; Vitamin B6 kinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Pyridoxal kinase protein (1-312AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
  • 基因功能参考文献：
    1. The affected pyridoxine metabolism is discussed as an inborn genetic trait in epilepsy in general, rather than a specific sign of pyridoxine-dependent epilepsy solely. PMID: 22647618
    2. The pyridoxal kinase showed decreased levels and was highly carbonylated in the gene-on mice PMID: 20639122
    3. This study identified a DNA variant (rs2010795) in PDXK associated with an increased risk of PD in the German cohort This association was confirmed in the British and Italian cohorts individually and reached a combined value. PMID: 20035503
    4. Pyridoxal kinase expression was compared in fetal Down syndrome (DS) brain and controls; PDXK levels were found to be similar. PMID: 15082224
    5. A promoter mutation with potential erythroid-specific properties that could be the basis of a novel mechanism of controlling cell-specific decreased activity of an essential enzyme in erythrocytes. PMID: 16704963
    6. The crystal structure of the MgATP complex also reveals Mg(2+) and Na(+) acting in tandem to anchor the ATP at the active site of pyridoxal kinase. PMID: 17766369
    7. These results document the role of Asp235 in PL kinase activity. PMID: 19351586

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  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Pyridoxine kinase family
  • 组织特异性：
    Ubiquitous. Highly expressed in testis.; [Isoform 3]: In adult testis and spermatozoa.
  • 数据库链接：

    HGNC: 8819

    OMIM: 179020

    KEGG: hsa:8566

    STRING: 9606.ENSP00000291565

    UniGene: Hs.284491