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PDZD3 Antibody

  • 货号：
    CSB-PA017753GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q86UT5
  • 基因名：
    PDZD3
  • 别名：
    IKEPP antibody; Intestinal and kidney enriched PDZ protein antibody; Intestinal and kidney-enriched PDZ protein antibody; Na(+)/H(+) exchange regulatory cofactor NHE-RF4 antibody; Na/Pi cotransporter C terminal associated protein 2 antibody; Na/Pi cotransporter C-terminal-associated protein 2 antibody; NaPi-Cap2 antibody; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2 antibody; NHERF-4 antibody; NHERF4 antibody; NHRF4_HUMAN antibody; PDZ domain containing 2 antibody; PDZ domain containing 3 antibody; PDZ domain containing protein 2 antibody; PDZ domain-containing protein 2 antibody; PDZ domain-containing protein 3 antibody; PDZD 3 antibody; Pdzd3 antibody; PDZK2 antibody; Protein DLNB27 antibody; Sodium-hydrogen exchanger regulatory factor 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PDZD3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
  • 基因功能参考文献：
    1. The NHERF4 is a novel modulator of luminal fluidity in the intestine by adjusting SLC26A3 expression and activity through a phosphorylation-dependent mechanism. PMID: 22627094
    2. IKEPP was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP PMID: 22884631
    3. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. PMID: 11950846
    4. Regulation of NHE3 depends on the nature of the NHERF family member associating with NHE3 and the accompanying NHE3 complexes. PMID: 19088451
  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cytoplasm.
  • 组织特异性：
    Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.
  • 数据库链接：

    HGNC: 19891

    OMIM: 607146

    KEGG: hsa:79849

    STRING: 9606.ENSP00000347742

    UniGene: Hs.374726