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PENK Antibody

  • 货号：
    CSB-PA994912
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of NT28 cells using Antibody diluted at 1000. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    P01210
  • 基因名：
    PENK
  • 别名：
    Leu-enkephalin antibody; Met-enkephalin antibody; Met-enkephalin-Arg-Gly-Leu antibody; Met-enkephalin-Arg-Phe antibody; Methionine enkephalin antibody; OGF antibody; Opioid growth factor antibody; PENK antibody; PENK(114-133) antibody; PENK(143-183) antibody; PENK(237-258) antibody; PENK_HUMAN antibody; PPA antibody; Proenkephalin A antibody; Proenkephalin antibody; Proenkephalin-A antibody; Synenkephalin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 51-100
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-10000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; Competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; Increases glutamate release in the striatum and decreases GABA concentration in the striatum.; Increases glutamate release in the striatum.
  • 基因功能参考文献：
    1. High PENK is associated with increased risk of CKD defined by eGFR in men, but not in women. No association of PENK with CKD defined by urinary albumin excretion UAE was observed. PMID: 29466891
    2. These results demonstrate that proinflammatory molecules and endogenous enkephalin have opposite gene regulation during Dry eye disease. PMID: 29673232
    3. These data indicate that in untrained women exercise training will not change resting of plasma Peptide F concentrations unless both forms of exercise are performed but will result in significant increases in the immediate post-exercise responses. PMID: 28263851
    4. The concentration of PENK 143-183 was significantly greater in patients with Moyamoya disease (MMD) than control patients and decreased in an age-dependent manner in MMD. PMID: 29030229
    5. Peptide F is bound to white blood cells in the blood. Exercise alters Peptide F in the plasma and white blood cell blood fractions. PMID: 23395721
    6. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons. PMID: 26634308
    7. The PENK polymorphism-and potentially opioid neurotransmission more generally-modulates functioning and structural integrity of brain regions. PMID: 26164485
    8. Serum PENK-A levels were not associated with all-cause mortality in patients with type 2 diabetes mellitus, and its association with cardiovascular mortality was strongly attenuated after accounting for all traditional risk factors. PMID: 26218633
    9. BSP demonstrated that emodin, to a certain degree, affected the demethylation of tumor-suppressor genes P16, RASSF1A, and ppENK in the pancreatic cancer cell line PANC-1. PMID: 25891176
    10. increased plasma PENK-A levels are associated with disease severity and in-hospital mortality after acute intracerebral hemorrhage. PMID: 24937654
    11. enhanced plasma proenkephalin A could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury. PMID: 24937655
    12. EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit PMID: 24496384
    13. Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical region exhibits nerve fibers expressing enkephalin (ENK); uterine fundus/corpus myoma pseudocapsules do not exhibit nerve fibers expressing ENK. PMID: 23937196
    14. Expression of preproenkephalin is significantly decreased in brain from HIV-1 infected patients compared to HIV-1 negative subjects. PMID: 22391864
    15. The findings suggest an important role for Neuroticism as an endophenotype linking PENK polymorphisms to cannabis-dependence vulnerability synergistically amplifying the apparent genetic risk. PMID: 22745721
    16. found higher levels for MOR mRNA (+27%) in schizophrenia but no differences in DOR or proenkephalin mRNAs PMID: 21810780
    17. Differential tertiary conformations of PE subdomains undergo ordered proteolytic processing to generate active enkephalin peptides for cell-cell communication in the nervous and endocrine systems. PMID: 22102294
    18. we demonstrated reduced ppE expression in patients with elevated psychological distress. PMID: 20628265
    19. indicate alterations of the cerebral PENK A- and PTA-system in both, dementia and acute neuroinflammatory disorders PMID: 20207019
    20. Results suggest that methylation-related inactivation of the ppENK gene is an intermediate or late event during pancreatic carcinogenesis. PMID: 12000709
    21. Proenkephalin peptide F has varying immunoreactivity in different circulatory biocompartments after exercise PMID: 16406203
    22. Proenkephalin A 119-159 is a stable proenkephalin A precursor fragment identified in human circulation PMID: 16621157
    23. The discrete cell-phenotype localization and timing of the changes in the level of PEA and of piGABA-R mRNA. PMID: 17074347
    24. Smoking was not associated with p16 or ppENK hypermethylation in pancreatic cancer patients PMID: 17198183
    25. study provides evidence that the growth-responsive nuclear protein, proenkephalin (Penk), is required, in part, for apoptosis induction, in response to activation or overexpression of p53 and RelA(p65) PMID: 17599100
    26. It found widespread expression of preproenkephalin (pPENK) mRNA and production of the enkephalin precursor protein proenkephalin (PENK) in rat and mouse tissues, as well as in tissues and cells from humans and pigs. PMID: 18082911

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted.
  • 蛋白家族：
    Opioid neuropeptide precursor family
  • 数据库链接：

    HGNC: 8831

    OMIM: 131330

    KEGG: hsa:5179

    STRING: 9606.ENSP00000324248

    UniGene: Hs.339831