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  4. PER1 Antibody

PER1 Antibody

  • 货号：
    CSB-PA017786GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O15534
  • 基因名：
    PER1
  • 别名：
    Circadian clock protein PERIOD 1 antibody; Circadian clock protein PERIOD1 antibody; Circadian pacemaker protein Rigui antibody; hPER 1 antibody; hPER antibody; hPER1 antibody; KIAA0482 antibody; MGC88021 antibody; PER 1 antibody; PER antibody; PER1 antibody; PER1 protein antibody; PER1_HUMAN antibody; Period 1 antibody; Period circadian protein homolog 1 antibody; Period drosophila homolog of antibody; Period homolog 1 antibody; Period1 antibody; RIGUI antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PER1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.
  • 基因功能参考文献：
    1. the strongest correlation was found between a decrease in placental PER1 expression and increased anxiety scores. Labour status was found to have a profound effect on mRNA expression. PMID: 30110692
    2. TNPO1-mediated nuclear import may constitute a novel input pathway of how cellular redox state signals to the clock, since redox stress increases binding of TNPO1 to PER1 and decreases its nuclear localization. TNPO1 is one of the novel players essential for normal circadian periods and potentially for redox regulation of the clock. PMID: 29377895
    3. the role of PER1 in carcinogenesis is exerted not only by regulating downstream genes, but also through the synergistic dysregulation of many other clock genes in the clock gene network. PMID: 27602964
    4. Per1 is regulated by microRNA-34a, a small non-coding RNA that directly binds to genes and inhibit gene expression. PMID: 26923637
    5. Low PER1 expression is associated with oral squamous cell carcinoma. PMID: 26943040
    6. Low Per1 gene expression is associated with colorectal liver metastases. PMID: 27492458
    7. The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy. PER1 c.2884C > G polymorphism may be associated with risk of non-response to HT in postmenopausal Korean women. PMID: 26624862
    8. ARNTL and PER1 were associated with PD. PMID: 26507264
    9. Collectively, these data show that KPNB1 is required for timely nuclear import of PER/CRY in the negative feedback regulation of the circadian clock. PMID: 26319354
    10. Period 1 and estrogen receptor-beta are downregulated in Chinese colon cancers. PMID: 26339386
    11. Data demonstrate a role for Per1 in the transcriptional regulation of NHE3 and SGLT1 in the kidney. PMID: 26377793
    12. In adipose tissue, acute sleep deprivation vs sleep increased methylation in two promoter-interacting enhancer regions of PER1 PMID: 26168277
    13. In patients with non-small cell lung cancer, loss of Per1 was correlated with poor differentiation, tumor status, high p-TNM stage and lymph node metastasis. Patients with lower expression of Per1, Per2 and Per3 had a shorter survival time. PMID: 25550826
    14. S714G mutation in hPER1 is associated with feeding rhythms and obesity in mice. PMID: 24857656
    15. The PER1 c.2247C> T and c.2884C> G polymorphisms singly and in combination were found to be related to the lumbar spine bone mineral density in postmenopausal Korean women. PMID: 24678593
    16. Functional SNPs found in PER1 were significantly associated with recurrence-free survival in a Chinese population with hepatocellular carcinoma. PMID: 25344870
    17. Fourteen proteins were identified to interact with per1 in tumor. PMID: 25863084
    18. PER1 and BMAL1 operate as cell-autonomous modulators of human pigmentation and may be targeted for future therapeutic strategies PMID: 25310406
    19. There is not a significant difference in the expression of CLOCK, BMAL1, and PER1 in buccal epithelial cells of patients with essential arterial hypertension regardless of patient genotype. PMID: 25070164
    20. findings suggested that the expression of hPER1 is regulated by miR-29a/b/c, which may also provide a new clue for the function of hPER1 PMID: 24578160
    21. Per1 and Per2 may play important roles in tumor development, invasion and prognosis, and Per2 may serve as a novel prognostic biomarker of human gastric cancer. PMID: 24551282
    22. Knockdown of either BMAL1 or Period1 in human anagen hair follicles significantly prolonged anagen. PMID: 24005054
    23. Casein kinase 1 primarily regulates the accumulating phase of the PER-CRY repressive complex by controlling the nuclear import rate. PMID: 24449901
    24. Per1 regulates aldosterone levels, and Per1 plays an integral role in the regulation of Na(+) retention. PMID: 24154698
    25. we identified the circadian clock PER1 mRNA as a novel substrate of the endoribonuclease activity of the unfolded protein response sensor IRE1alpha PMID: 23752693
    26. Loss of PER1 expression is associated with proliferation and metastasis of buccal squamous cell carcinoma. PMID: 23405233
    27. Data suggest that clock genes Per1, Cry1, Clock, and Bmal1 and their protein products may be directly involved in the daytime-dependent regulation and adaptation of hormone synthesis. PMID: 23584858
    28. Studies indicate that in the cytoplasm, PER3 protein heterodimerizes with PER1, PER2, CRY1, and CRY2 proteins and enters into the nucleus, resulting in repression of CLOCK-BMAL1-mediated transcription. PMID: 23546644
    29. Loss of Per1 expression is associated with skin tumors. PMID: 23242607
    30. type II protein arginine methyltransferase 5 has a role in the regulation of Circadian Per1 and CRY1 genes PMID: 23133559
    31. Expression of the CLOCK, BMAL1, and PER1 circadian genes in human oral mucosa cells as dependent on CLOCK gene polymorphic variants. PMID: 23129285
    32. A common polymorphism near PER1 is associated with the timing of human behavioral rhythms, and shows evidence of association with time of death. PMID: 23034908
    33. dose-specific glucocorticoid responses are specific, able to distinctly express a single gene,PER1; mapped PER1 response to a single GR binding site; overexpression of PER1 led to regulation of additional circadian rhythm genes suggesting hypersensitive expression of PER1 impacts circadian gene expression PMID: 22801371
    34. treatment with isoprenaline or dexamethasone induces circadian expression of hPer1, hPer2, hPer3, and hBMAL1 PMID: 22217103
    35. PER1 and PER3 may modulate apoptotic reactions to cisplatin in gingival cancer cells PMID: 21459569
    36. Overexpression of the Bmal1 gene and reduced expression of the Per1 gene may thus be useful predictors of liver metastasis. PMID: 21380491
    37. Lean individuals exhibited significant (P < 0.05) temporal changes of core clock (PER1, PER2, PER3, CRY2, BMAL1, and DBP) and metabolic (REVERBalpha, RIP140, and PGC1alpha) genes. PMID: 21411511
    38. There were no significant differences in PER1 expression between patients with Alzheimer's dementia, those with mild cognitive impairment, and controls. An increase in PER1 expression during the wake stage is observed for all three groups. PMID: 20541418
    39. ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression PMID: 20861012
    40. We found that overnight expression of BMAL1, but not PER1, was reduced in Parkinson's disease. Because our sampling span was limited to 12 h, we cannot rule out the possibility that PER1 is expressed differently during the unsampled part of the day. PMID: 19912323
    41. direct interaction between RACK1 and PER1 PMID: 17718421
    42. The expression levels of Per1 in glioma cells were significantly different from the surrounding non-glioma cells. The difference in the expression rate of Per1 in high-grade (grade III and IV) and low-grade (grade 1 and II) gliomas was insignificant. PMID: 20481271
    43. PER1 acts as an anti-apoptotic factor in pancreatic cancer cells PMID: 19675098
    44. Sleep-wake cycles have been shown to influence the rhythmic mRNA expression of clock genes in peripheral blood cells of healthy participants PMID: 19861640
    45. human Per1 (hPER1) reporter gene activity shows circadian rhythmicity in a human neuroblastoma, but not in a astrocytoma or a hepatoma cell line. PMID: 12916719
    46. Circadian oscillations of Per1, Per2, and Per3 mRNA expression were observed in serum-stimulated normal human fibroblasts. PMID: 14712925
    47. Circadian hPER1 degradation through a proteasomal pathway can be regulated through phosphorylation by CKI, but not by subcellular localization. The mRNA levels reached a maximum at 1 h & minimal levels at 12 h. PMID: 14750904
    48. physical chemistry and three-dimensional structure of the protein transduction domain PMID: 15781181
    49. disturbances in PER gene expression may result in disruption of the control of the normal circadian clock, thus benefiting the survival of cancer cells and promoting carcinogenesis PMID: 15790588
    50. RNA interference against beta-TRCP greatly decreases Clock-dependent gene expression in tissue culture cells, indicating that beta-TRCP controls endogenous Per1 activity and the circadian clock by directly targeting Per1 for degradation PMID: 15917222

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Widely expressed. Expressed in hair follicles (at protein level).Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle.
  • 数据库链接：

    HGNC: 8845

    OMIM: 602260

    KEGG: hsa:5187

    STRING: 9606.ENSP00000314420

    UniGene: Hs.445534